Addressing the benefits of inhibiting APOBEC3-dependent mutagenesis in cancer
Mutational signatures associated with apolipoprotein B mRNA-editing enzyme catalytic
polypeptide-like (APOBEC) 3 cytosine deaminase activity have been found in over half of …
polypeptide-like (APOBEC) 3 cytosine deaminase activity have been found in over half of …
The APOBEC protein family: united by structure, divergent in function
JD Salter, RP Bennett, HC Smith - Trends in biochemical sciences, 2016 - cell.com
The APOBEC (apolipoprotein B mRNA editing catalytic polypeptide-like) family of proteins
have diverse and important functions in human health and disease. These proteins have an …
have diverse and important functions in human health and disease. These proteins have an …
Mechanisms of APOBEC3 mutagenesis in human cancer cells
M Petljak, A Dananberg, K Chu, EN Bergstrom… - Nature, 2022 - nature.com
The APOBEC3 family of cytosine deaminases has been implicated in some of the most
prevalent mutational signatures in cancer,–. However, a causal link between endogenous …
prevalent mutational signatures in cancer,–. However, a causal link between endogenous …
APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer
The single-stranded DNA cytosine-to-uracil deaminase APOBEC3B is an antiviral protein
implicated in cancer. However, its substrates in cells are not fully delineated. Here …
implicated in cancer. However, its substrates in cells are not fully delineated. Here …
Cellular APOBEC3A deaminase drives mutations in the SARS-CoV-2 genome
Y Nakata, H Ode, M Kubota, T Kasahara… - Nucleic Acids …, 2023 - academic.oup.com
The number of genetic variations in the SARS-CoV-2 genome has been increasing primarily
due to continuous viral mutations. Here, we report that the human APOBEC3A (A3A) cytidine …
due to continuous viral mutations. Here, we report that the human APOBEC3A (A3A) cytidine …
An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers
SA Roberts, MS Lawrence, LJ Klimczak, SA Grimm… - Nature …, 2013 - nature.com
Recent studies indicate that a subclass of APOBEC cytidine deaminases, which convert
cytosine to uracil during RNA editing and retrovirus or retrotransposon restriction, may …
cytosine to uracil during RNA editing and retrovirus or retrotransposon restriction, may …
Evidence for APOBEC3B mutagenesis in multiple human cancers
Thousands of somatic mutations accrue in most human cancers, and their causes are
largely unknown. We recently showed that the DNA cytidine deaminase APOBEC3B …
largely unknown. We recently showed that the DNA cytidine deaminase APOBEC3B …
APOBEC3B is an enzymatic source of mutation in breast cancer
Several mutations are required for cancer development, and genome sequencing has
revealed that many cancers, including breast cancer, have somatic mutation spectra …
revealed that many cancers, including breast cancer, have somatic mutation spectra …
Induction of APOBEC3 exacerbates DNA replication stress and chromosomal instability in early breast and lung cancer evolution
S Venkatesan, M Angelova, C Puttick, H Zhai… - Cancer discovery, 2021 - AACR
APOBEC3 enzymes are cytosine deaminases implicated in cancer. Precisely when
APOBEC3 expression is induced during cancer development remains to be defined. Here …
APOBEC3 expression is induced during cancer development remains to be defined. Here …
HIV restriction factors and mechanisms of evasion
MH Malim, PD Bieniasz - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Retroviruses have long been a fertile model for discovering host–pathogen interactions and
their associated biological principles and processes. These advances have not only …
their associated biological principles and processes. These advances have not only …