Manufacturing of solid dispersions of poorly water soluble drugs by spray drying: formulation and process considerations

A Paudel, ZA Worku, J Meeus, S Guns… - International journal of …, 2013 - Elsevier
Spray drying is an efficient technology for solid dispersion manufacturing since it allows
extreme rapid solvent evaporation leading to fast transformation of an API-carrier solution to …

Pharmaceutical Particle Engineering via Spray Drying

R Vehring - Pharmaceutical research, 2008 - Springer
This review covers recent developments in the area of particle engineering via spray drying.
The last decade has seen a shift from empirical formulation efforts to an engineering …

Wetting, disintegration and dissolution of agglomerated water soluble powders

L Forny, A Marabi, S Palzer - Powder Technology, 2011 - Elsevier
Agglomeration technologies are commonly used by the food industry to optimize several
properties such as density and flowability and also to shorten the reconstitution time of …

Physical characterization and stability of amorphous indomethacin and ranitidine hydrochloride binary systems prepared by mechanical activation

N Chieng, J Aaltonen, D Saville, T Rades - European Journal of …, 2009 - Elsevier
Co-milling of γ-indomethacin and ranitidine hydrochloride form 2 at various weight ratios (1:
2, 1: 1 and 2: 1) was investigated with a particular interest in the physicochemical properties …

[PDF][PDF] Drug-excipient behavior in polymeric amorphous solid dispersions

SB Teja, SP Patil, G Shete, S Patel… - International Journal …, 2016 - jefc.scholasticahq.com
Amorphous drug delivery systems are increasingly utilized to enhance aqueous solubility
and oral bioavailability. However, they lack physical and/or chemical stability. One of the …

Phase transition enthalpy measurements of organic and organometallic compounds and ionic liquids. Sublimation, vaporization, and fusion enthalpies from 1880 to …

W Acree, JS Chickos - Journal of Physical and Chemical Reference …, 2017 - pubs.aip.org
This compendium completes a previous report published in 2016 [2016ACR/CHI] on phase
change enthalpies. Paper I of this compendium includes over 6600 organic compounds …

Development, characterization and stabilization of amorphous form of a low Tg drug

VB Pokharkar, LP Mandpe, MN Padamwar… - Powder technology, 2006 - Elsevier
The objective of the present study was to develop a stable amorphous form of model drug
carvedilol (CAR). The amorphous material produced by melt quench technique was …

Spray-Dried Amorphous Solid Dispersions of Simvastatin, a Low Tg Drug: In Vitro and in Vivo Evaluations

AA Ambike, KR Mahadik, A Paradkar - Pharmaceutical research, 2005 - Springer
Purpose To obtain free flowing, stable, amorphous solid dispersions (SDs) of simvastatin
(SIM), a drug with relatively lower glass transition temperature (T g) by spray drying …

Effects of polymer type and storage relative humidity on the kinetics of felodipine crystallization from amorphous solid dispersions

ACF Rumondor, LA Stanford, LS Taylor - Pharmaceutical research, 2009 - Springer
Purpose The objective of this study was to investigate the effects of polymer type and
storage relative humidity (RH) on the crystallization kinetics of felodipine from amorphous …

Crystallization tendency of active pharmaceutical ingredients following rapid solvent evaporation—classification and comparison with crystallization tendency from …

B Van Eerdenbrugh, JA Baird, LS Taylor - Journal of pharmaceutical …, 2010 - Elsevier
In this study, the crystallization behavior of a variety of compounds was studied following
rapid solvent evaporation using spin coating. Initial screening to determine model …