Neuroinflammation, stroke, blood-brain barrier dysfunction, and imaging modalities

E Candelario-Jalil, RM Dijkhuizen, T Magnus - Stroke, 2022 - Am Heart Assoc
Maintaining blood-brain barrier (BBB) integrity is crucial for the homeostasis of the central
nervous system. Structurally comprising the BBB, brain endothelial cells interact with …

Seizures and epilepsy in patients with ischaemic stroke

JP Zöllner, FC Schmitt, F Rosenow, K Kohlhase… - … Research and Practice, 2021 - Springer
Background With the increased efficacy of stroke treatments, diagnosis and specific
treatment needs of patients with post-stroke seizures (PSS) and post-stroke epilepsy have …

Perfusion abnormalities on 24-hour perfusion imaging in patients with complete endovascular reperfusion

A Mujanovic, A Imhof, S Zheng, EI Piechowiak… - Stroke, 2024 - ahajournals.org
BACKGROUND: Perfusion abnormalities in the infarct and salvaged penumbra have been
proposed as a potential reason for poor clinical outcome (modified Rankin Scale score> 2) …

Hyperperfusion profiles after recanalization differentially associate with outcomes in a rat ischemic stroke model

BAA Franx, GAF Van Tilborg, A Taha… - Journal of Cerebral …, 2024 - journals.sagepub.com
Futile recanalization hampers prognoses of ischemic stroke after successful mechanical
thrombectomy, hypothetically through post-recanalization perfusion deficits, onset-to-groin …

Incidence, severity and impact on functional outcome of persistent hypoperfusion despite large-vessel recanalization, a potential marker of impaired microvascular …

A Schiphorst, G Turc, WB Hassen… - Journal of Cerebral …, 2024 - journals.sagepub.com
The reported incidence of persistent hypoperfusion despite complete recanalization as
surrogate for impaired microvascular reperfusion (IMR) has varied widely among clinical …

Blood Oxygenation Level–Dependent Cerebrovascular Reactivity–Derived Steal Phenomenon May Indicate Tissue Reperfusion Failure After Successful …

J Bellomo, M Sebök, V Stumpo, CHB van Niftrik… - Translational Stroke …, 2023 - Springer
In acute ischemic stroke due to large-vessel occlusion (LVO), the clinical outcome after
endovascular thrombectomy (EVT) is influenced by the extent of autoregulatory …

Priorities for advancements in neuroimaging in the diagnostic workup of acute stroke

EA Samaniego, J Boltze, PD Lyden, MD Hill… - Stroke, 2023 - Am Heart Assoc
STAIR XII (12th Stroke Treatment Academy Industry Roundtable) included a workshop to
discuss the priorities for advancements in neuroimaging in the diagnostic workup of acute …

Post-reperfusion hyperperfusion after endovascular stroke treatment: a prospective comparative study of TCD versus MRI

M Kneihsl, N Hinteregger, O Nistl… - Journal of …, 2023 - jnis.bmj.com
Background Increased middle cerebral artery (MCA) blood flow velocities on transcranial
duplex sonography (TCD) were recently reported in individual patients after successful …

Implications of post-recanalization perfusion deficit after acute ischemic stroke: a scoping review of clinical and preclinical imaging studies

N van der Knaap, BAA Franx, CBLM Majoie… - Translational Stroke …, 2024 - Springer
The goal of reperfusion therapy for acute ischemic stroke (AIS) is to restore cerebral blood
flow through recanalization of the occluded vessel. Unfortunately, successful recanalization …

Role of blood–brain barrier dysfunction in the development of poststroke epilepsy

WC Meijer, JA Gorter - Epilepsia, 2024 - Wiley Online Library
Stroke is a major contributor to mortality and morbidity worldwide and the most common
cause of epilepsy in the elderly in high income nations. In recent years, it has become …