Calcineurin inhibitors (CNI), including cyclosporine A (CsA) and tacrolimus (TAC), are
cornerstones of immunosuppressive therapy in solid organ transplant recipients. While …

Vitis vinifera (grape) is one of the “most‐produced fruit” in the world. Grape seeds are a
valuable source of phenolic compounds including resveratrol (RSV). Grape and one of its …

Grape seed procyanidin B2 (GSPB2) was reported to have protective effects on diabetic
nephropathy (DN) as a strong antioxidant. Our previous studies demonstrated that GSPB2 …

Aims Acute myocardial infarction is a serious acute cardiac disorder and heart disease is still
a major public health problem in adults. We investigated the effects of embelin (EMB) and …

The conventional view of using medicines as routine treatment of an intractable disease is
being challenged in the face of extensive and growing evidence that flavonoids in foods …

Cyclosporine is one of the main immunosuppressive agents used in the treatment of
autoimmune diseases or transplantation. Despite the favorable effects, cyclosporine …

We aimed to investigate the effects of grape seed extract (GSE) and vitamin E (Vit E) on
oxidative stress and apoptosis in the hippocampus of streptozotocin-induced diabetic rats. In …

A significant decrease in poultry egg production occurs due to ovarian aging and autophagy
is one of the important factors of ovarian aging that is induced predominantly by oxidative …

Due to the widely application of Cyclosporine A (CsA) as an immunosuppressant in clinic, it
is necessary to study its potential toxicity. Therefore, we used zebrafish as a model animal to …

Cyclosporine A is an immunosuppressive drug used after organ's transplantation. The
adverse effects on such organs as kidney or liver may limit its use. Oxidative stress is …