Metabolic adaptation to viral infections critically determines the course and manifestations of
disease. At the systemic level, a significant feature of viral infection and inflammation that …

Human endogenous retroviruses (HERVs) are relics of ancient infections accounting for
about the 8% of our genome. Despite their persistence in human DNA led to the …

Osteoclasts (OCLs) are hematopoietic cells whose physiological function is to degrade
bone. OCLs are key players in the processes that determine and maintain the mass, shape …

Relative to other neutral amino acid transporters, the expression levels of ASCT2 and LAT1,
are coordinately elevated in a wide spectrum of primary human cancers, suggesting that …

Screening human sequence databases for endogenous retroviral elements with coding
envelope genes has revealed 16 candidate genes that we assayed for their fusogenic …

For millions of years, retroviral infections have challenged vertebrates, occasionally leading
to germline integration and inheritance as ERVs, genetic parasites whose remnants today …

Retroelements constitute a large portion of our genomes. One class of these elements, the
human endogenous retroviruses (HERVs), is comprised of remnants of ancient exogenous …

Prion-like spreading of protein misfolding is a characteristic of neurodegenerative diseases,
but the exact mechanisms of intercellular protein aggregate dissemination remain …

The capacity to integrate into the chromosomal DNA of germ-line cells has endowed
retroviruses with the potential to be vertically transmitted from generation to generation and …

Human ASCT2 belongs to the SLC1 family of secondary transporters and is specific for the
transport of small neutral amino acids. ASCT2 is upregulated in cancer cells and serves as …