Since the advent of Hi-C in 2009, a plethora of high-throughput sequencing methods have
emerged to profile the three-dimensional (3D) organization of eukaryotic genomes, igniting …

The invention of chromosome conformation capture (3C) techniques, in particular the key
method Hi-C providing genome-wide information about chromatin contacts, revolutionized …

Abstract Single-cell Hi-C (scHi-C) technologies allow for probing of genome-wide cell-to-cell
variability in three-dimensional (3D) genome organization from individual cells …

Determining how chromatin is structured in the nucleus is critical to studying its role in gene
regulation. Recent advances in the analysis of single-cell chromatin architecture have …

Highlights•3D genome organization undergoes dramatic changes in cancer.•Oncogenes
can be ectopically activated by SV-induced enhancer hijacking.•Tumor suppressor genes …

Eukaryotic genomes are spatially organized inside the cell nucleus, forming a
threedimensional (3D) architecture that allows for spatial separation of nuclear processes …

Advances in chromatin mapping have exposed the complex chromatin hierarchical
organization in mammals, including topologically associating domains (TADs) and their …

Single-cell Hi-C data provides valuable insights into the three-dimensional organization of
chromatin within individual cells, yet modeling this data poses significant challenges due to …

Deciphering cell identity genes is pivotal to understanding cell differentiation, development,
and many diseases involving cell identity dysregulation. Here, we introduce SCIG, a …

Recent advances chromatin capture, imaging techniques, and polymer modeling have
dramatically enhanced quantitative understanding of chromosomal folding. However, the …