Human mesenchymal stem cells (MSCs) for treatment towards immune-and inflammation-mediated diseases: review of current clinical trials

LT Wang, CH Ting, ML Yen, KJ Liu, HK Sytwu… - Journal of biomedical …, 2016 - Springer
Human mesenchymal stem cells (MSCs) are multilineage somatic progenitor/stem cells that
have been shown to possess immunomodulatory properties in recent years. Initially met with …

The critical role of apoptosis in mesenchymal stromal cell therapeutics and implications in homeostasis and normal tissue repair

C Giacomini, C Granéli, R Hicks, F Dazzi - Cellular & Molecular …, 2023 - nature.com
Mesenchymal stromal cells (MSCs) have been extensively tested for the treatment of
numerous clinical conditions and have demonstrated good safety but mixed efficacy …

Immunomodulation by therapeutic mesenchymal stromal cells (MSC) is triggered through phagocytosis of MSC by monocytic cells

SFH de Witte, F Luk, JM Sierra Parraga, M Gargesha… - stem cells, 2018 - academic.oup.com
Mesenchymal stem or stromal cells (MSC) are under investigation as a potential
immunotherapy. MSC are usually administered via intravenous infusion, after which they are …

Immunomodulatory effects of mesenchymal stromal cells-derived exosome

W Chen, Y Huang, J Han, L Yu, Y Li, Z Lu, H Li… - Immunologic …, 2016 - Springer
The mechanisms underlying immunomodulatory ability of mesenchymal stromal cells
(MSCs) remain unknown. Recently, studies suggested that the immunomodulatory activity of …

Current perspectives on mesenchymal stromal cell therapy for graft versus host disease

N Kadri, S Amu, E Iacobaeus, E Boberg… - Cellular & Molecular …, 2023 - nature.com
Graft versus host disease (GvHD) is the clinical condition in which bone marrow-derived
mesenchymal stromal cells (MSCs) have been most frequently studied. In this review, we …

[HTML][HTML] A phase 3, single-arm, prospective study of remestemcel-L, ex vivo culture-expanded adult human mesenchymal stromal cells for the treatment of pediatric …

J Kurtzberg, H Abdel-Azim, P Carpenter… - Biology of Blood and …, 2020 - Elsevier
Steroid-refractory acute graft-versus-host disease (SR-aGVHD) following hematopoietic cell
transplantation (HSCT) is associated with poor clinical outcomes. Currently, there are no …

Specificity of 3D MSC spheroids microenvironment: impact on MSC behavior and properties

A Jauković, D Abadjieva, D Trivanović… - Stem cell reviews and …, 2020 - Springer
Mesenchymal stem cells (MSC) have been considered the promising candidates for the
regenerative and personalized medicine due to their self-renewal potential, multilineage …

Inactivated mesenchymal stem cells maintain immunomodulatory capacity

F Luk, SFH De Witte, SS Korevaar… - Stem cells and …, 2016 - liebertpub.com
Mesenchymal stem cells (MSC) are studied as a cell therapeutic agent for treatment of
various immune diseases. However, therapy with living culture-expanded cells comes with …

Low immunogenicity of allogeneic human umbilical cord blood-derived mesenchymal stem cells in vitro and in vivo

M Lee, SY Jeong, J Ha, M Kim, HJ Jin, SJ Kwon… - Biochemical and …, 2014 - Elsevier
Abstract Evaluation of the immunogenicity of human mesenchymal stem cells (MSCs) in an
allogeneic setting during therapy has been hampered by lack of suitable models due to …

Interferon-gamma modification of mesenchymal stem cells: implications of autologous and allogeneic mesenchymal stem cell therapy in allotransplantation

KN Sivanathan, S Gronthos, D Rojas-Canales… - Stem cell reviews and …, 2014 - Springer
Bone marrow-derived mesenchymal stem cells (MSC) have unique immunomodulatory and
reparative properties beneficial for allotransplantation cellular therapy. The clinical …