As a type of lytic cell death driven by unrestricted lipid peroxidation and subsequent plasma
membrane damage, ferroptosis occurs and develops because of sophisticated signals and …

Sphingomyelin synthase (SMS), which comprises of two isozymes, SMS1 and SMS2, is the
only enzyme that generates sphingomyelin (SM) by transferring phosphocholine of …

Abstract Glutathione peroxidase 4 (GPX4) has been confirmed to inhibit ferroptosis in cancer
cells, however, whether GPX4 serves as an oncogene is not clear. In this study, the …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Selective degradation of the endoplasmic reticulum (ER; reticulophagy) is a type of
autophagy involved in the removal of ER fragments. So far, amino acid starvation as well as …

Regulated cell death is a widely attractive subject among the topics of cancer therapy and
has gained some advances for discovery of targeted anticancer drugs. In the past decade …

Background: Ferroptosis is a newly proposed form of programmed cell death, and
accumulating evidence suggests that it plays an essential role in the development of …

Cell death is a natural biological process that occurs in living organisms. Since 1963,
extensive research has shed light on the occurrence, progress, and final outcome of cell …

Increasing evidence suggests that induction of lethal macroautophagy/autophagy carries
potential significance for the treatment of glioblastoma (GBM). In continuation of previous …

Incomplete radiofrequency ablation (IRFA) triggers mild protective autophagy in residual
tumor cells and results in an immunosuppressive microenvironment. This accelerates the …