Due to concealment, high invasiveness and a lack of indicators, malignant tumors have
emerged as one of the deadliest diseases worldwide and their incidence is rising yearly …

Maintenance of the cellular proteome or proteostasis is an essential process that when
deregulated leads to diseases like neurological disorders and cancer. Central to …

How the essential eukaryotic chaperonin TRiC/CCT assembles from eight distinct subunits
into a unique double-ring architecture remains undefined. We show TRiC assembly involves …

The chaperonins CCT and Hsp60 are molecular chaperones, members of the chaperone
system (CS). Chaperones are cytoprotective but if abnormal in quantity or quality they may …

Knowledge of RNA molecules regulating testicular development and spermatogenesis in
bulls is essential for elite bull selection and an ideal breeding program. Herein, we …

Background Chaperonin-containing TCP-1 (TRiC or CCT) was demonstrated to be involved
in oncogenesis of cancers carcinogenesis and development of various malignancies …

T-complex protein-1 ring complex (TRiC), also known as Chaperonin Containing T-complex
protein-1 (CCT), is a multisubunit chaperonin required for the folding of nascent proteins …

Background CCT3 is a subunit of chaperonin-containing TCP-1 (CCT), which folds many
proteins involved in cancer development and plays an important role in many cancers …

Chaperonin containing TCP1 (CCT/TRiC) is a multi-subunit protein folding complex that
enables the cancer phenotype to emerge from the mutational landscape that drives …

Background Disrupted protein homeostasis (proteostasis) has been demonstrated to
facilitate the progression of various diseases. The cytosolic T‐complex protein‐1 ring …