Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and
indole pathways. A variety of bioactive compounds produced via Trp metabolism can …

I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …

Irritable bowel syndrome (IBS) is a highly prevalent, chronic disorder that significantly
reduces patients' quality of life. Advances in diagnostic testing and in therapeutic options for …

Abstract According to the United States Centers for Disease Control and Prevention (CDC),
as of July 11, 2016, the reported average incidence of children diagnosed with an autism …

During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …

Abstract Serotonin (5-HT) has been recognized for decades as an important signalling
molecule in the gut, but it is still revealing its secrets. Novel gastrointestinal functions of 5-HT …

Several recent studies describe the influence of the gut microbiota on host brain and
behavior. However, the mechanisms responsible for microbiota-nervous system interactions …

The 'microbiota-gut-brain axis' plays a fundamental role in maintaining host homeostasis,
and different immune, hormonal, and neuronal signals participate to this interkingdom …

The gut–brain axis refers to the bidirectional communication between the gut and brain, and
regulates intestinal homeostasis and the central nervous system via neural networks and …

Serotonin is an important gastrointestinal signaling molecule. It is a paracrine messenger
utilized by enterochromaffin (EC) cells, which function as sensory transducers. Serotonin …