Age-related macular degeneration (AMD) is a complex and multifactorial disease and a
leading cause of irreversible blindness in the elderly population. The anti-vascular …

Cell-type-specific in vivo delivery of genome editing molecules is the next breakthrough that
will drive biological discovery and transform the field of cell and gene therapy. Here, we …

The complexity of the human eye structure poses challenges in the diagnosis and treatment
of ocular diseases, especially the low efficiency of ocular drug delivery. With the continuous …

Abstract Poly (ethylene glycol)(PEG)–lipids are used in Food‐and‐Drug‐Administration‐
approved lipid nanoparticle (LNP)–RNA drugs, which are safe and effective. However, it is …

Lipid nanoparticles (LNPs) represent the forefront of mRNA delivery platforms, yet achieving
precise delivery to specific cells remains a challenge. The current targeting strategies …

Previously, researchers have employed Lipid nanoparticles (LNPs) to directly encapsulate
medicines. In the realm of gene therapy, researchers have begun to employ lipid …

Abstract mRNA therapeutics have shown great potential for a broad spectrum of disease
treatment. However, the challenges of mRNA's inherent instability and difficulty in cellular …

Millions of people worldwide have hereditary genetic disorders, trauma, infectious diseases,
or cancer of the eyes, and many of these eye diseases lead to irreversible blindness, which …

Complete encapsulation of nucleic acids by lipid‐based nanoparticles (LNPs) is often
thought to be one of the main prerequisites for successful nucleic acid delivery, as the lipid …

T-cell exhaustion refers to a state of T-cell dysfunction commonly observed in chronic
infections and cancer. Immune checkpoint molecules blockading using PD-1 and TIM-3 …