DNA damage, largely owing to oxidative stress, is a leading cause of defective sperm
function. High levels of oxidative stress result in damage to sperm DNA, RNA transcripts …

We herein summarise the evidence concerning the impact of sperm DNA fragmentation in
various clinical infertility scenarios and the advances on sperm DNA fragmentation tests …

Oxidative stress plays a major role in the life and death of mammalian spermatozoa. These
gametes are professional generators of reactive oxygen species (ROS), which appear to …

Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The
spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases …

Oxidative stress (OS) represents a threat to the chemical integrity of biomolecules including
lipids, proteins, and DNA. The associated molecular damage frequently results in serious …

Reactive oxygen species (ROS) have been extensively studied as a cause of male infertility.
Excessive levels of ROS coupled with a deficiency in antioxidants can lead to oxidative …

Spermatozoa are highly vulnerable to oxidative attack because they lack significant
antioxidant protection due to the limited volume and restricted distribution of cytoplasmic …

Over the last decade, there has been a significant increase in average paternal age when
the first child is conceived, either due to increased life expectancy, widespread use of …

One of the major causes of defective sperm function is oxidative stress, which not only
disrupts the integrity of sperm DNA but also limits the fertilizing potential of these cells as a …

BACKGROUND A defining feature of sexual reproduction is the transmission of genomic
information from both parents to the offspring. There is now compelling evidence that the …