Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Degenerative cervical myelopathy (DCM) is the leading cause of spinal cord dysfunction in
adults worldwide. DCM encompasses various acquired (age-related) and congenital …

Nucleic acid aptamers can be selected from pools of random-sequence oligonucleotides to
bind a wide range of biomedically relevant proteins with affinities and specificities that are …

Necroptosis is a form of regulated necrosis that can be activated by ligands of death
receptors and stimuli that induce the expression of death receptor ligands under apoptotic …

Spinal cord injury (SCI) often leads to persistent functional deficits due to loss of neurons
and glia and to limited axonal regeneration after injury. Here we report that transplantation of …

During the past two decades, an important focus of pain research has been the study of
chronic pain mechanisms, particularly the processes that lead to the abnormal sensitivity …

Injury to the central nervous system (CNS) results in oligodendrocyte cell death and
progressive demyelination. Demyelinated axons undergo considerable physiological …

Apoptosis is a highly regulated process of cell deletion and plays a fundamental role in the
maintenance of tissue homeostasis in the adult organism. Numerous studies in recent years …

Abstract CD95 (APO-1/Fas) is a member of the death receptor (DR) family. Stimulation of
CD95 leads to induction of apoptotic and non-apoptotic signaling pathways. The formation …

Wallerian degeneration (WD) is the set of molecular and cellular events by which
degenerating axons and myelin are cleared after injury. Why WD is rapid and robust in the …