Nutrients such as glucose, amino acids and lipids are fundamental sources for the
maintenance of essential cellular processes and homeostasis in all organisms. The nutrient …

Autosomal dominant polycystic kidney disease is the most common monogenic cause of
ESKD. Genetic studies from patients and animal models have informed disease …

Initiation of cyst formation in autosomal dominant polycystic kidney disease (ADPKD) occurs
when kidney tubule cells are rendered null for either PKD1 or PKD2 by somatic 'second …

Mild reduction in food intake was recently shown to slow polycystic kidney disease (PKD)
progression in mouse models, but whether the effect was due to solely reduced calories or …

Ketogenic dietary interventions (KDIs) are beneficial in animal models of autosomal-
dominant polycystic kidney disease (ADPKD). KETO-ADPKD, an exploratory, randomized …

Autosomal dominant polycystic kidney disease (ADPKD) is generally a late-onset
multisystem disorder characterized by bilateral kidney cysts, liver cysts, and an increased …

Silica nanoparticles (SiNPs) released during the burning of sugarcane have been
postulated to have a role in chronic kidney disease of unknown etiology. We tested the …

Background Our laboratory published the first evidence that nutritional ketosis, induced by a
ketogenic diet (KD) or time-restricted diet (TRD), ameliorates disease progression in …

Treatment with sodium-glucose cotransporter-2 (SGLT2) inhibitors may have pleiotropic and
beneficial effects in terms of ameliorating of risk factors for the progression of autosomal …

Abstract L-ergothioneine (L-egt) is a bioactive compound recently approved by the food and
drug administration as a supplement. L-egt exerts potent cyto-protective, antioxidant and anti …