Purpose: To evaluate the effect of folate and folate plus zinc supplementation on endocrine
parameters and sperm characteristics in sub fertile men. Materials and Methods: We …

Infertility affects nearly 50 million couples worldwide, with 40− 50% of cases having a male
factor component. It is well established that nutritional status impacts reproductive …

Background and Objectives Methylenetetrahydrofolate reductase (MTHFR) polymorphism
may be a risk factor for male infertility. However, the epidemiologic studies showed …

Background Epidemiological studies have reported that polymorphisms of folate-
metabolizing genes have a significant impact on male infertility. However, the results of …

Several studies showed that the genetic mutations in the folate-related enzyme genes might
be associated with male infertility; however, the results were still inconsistent. We performed …

Methylenetetrahydrofolate reductase (MTHFR) functions as a main regulatory enzyme in
folate metabolism. The association of MTHFR gene Ala222Val polymorphism with male …

Spermatogenesis is a process where an important contribution of genes involved in folate-
mediated one-carbon metabolism is observed. The aim of the present study was to …

ABSTRACT Research Question Is there any genetic association between oestrogen
receptor alpha [ERα]-PvuII polymorphism and idiopathic male infertility? Design A total of …

Abstract Background Whether MTHFR C677T genotype affects pregnancy outcomes
following assisted reproductive technology is conflicting. And the role of MTHFR C677T …

Male infertility is a multifactorial syndrome encompassing a wide variety of disorders. In
recent years, several genome-wide single-nucleotide polymorphism (SNP) association …