G protein-coupled receptors (GPCRs) are the largest single family of cell surface receptors
encoded by the human genome and they play pivotal roles in co-ordinating cellular systems …

Membrane proteins are highly diverse in both structure and function and can, therefore,
present different challenges for structure determination. They are biologically important for …

Docosahexaenoic acid is an omega-3 fatty acid that is essential for neurological
development and function, and it is supplied to the brain and eyes predominantly from …

Metabotropic γ-aminobutyric acid G protein–coupled receptors (GABAB) represent one of
the two main types of inhibitory neurotransmitter receptors in the brain. These receptors act …

Detergents are widely used for membrane protein solubilization, purification, and structural
analysis. Over the past two decades, much effort has been made to design novel detergents …

Cryo–electron microscopy (cryo-EM) continues its remarkable growth as a method for
visualizing biological objects, which has been driven by advances across the entire pipeline …

Membrane proteins are often challenging targets for native top-down mass spectrometry
experimentation. The requisite use of membrane mimetics to solubilize such proteins …

Cryo-EM grid preparation is an important bottleneck in protein structure determination,
especially for membrane proteins, typically requiring screening of a large number of …

The solubilisation of membrane proteins (MPs) necessitates the overlap of two contradictory
events; the extraction of MPs from their native lipid membranes and their subsequent …

Until now, membrane-protein stabilization has relied on iterations of mutations and
screening. We now validate a one-step algorithm, mPROSS, for stabilizing membrane …