Piperidine nucleus as a promising scaffold for alzheimer's disease: current landscape and future perspective

P Grover, S Rohilla, M Bhardwaj… - Current Topics in …, 2023 - ingentaconnect.com
Heterocycles and their derivatives hold an important place in medicinal chemistry due to
their vast therapeutic and pharmacological significance and wider implications in drug …

[HTML][HTML] Recent Advances in Therapeutics for the Treatment of Alzheimer's Disease

AM Thawabteh, AW Ghanem, S AbuMadi, D Thaher… - Molecules, 2024 - mdpi.com
The most prevalent chronic neurodegenerative illness in the world is Alzheimer's disease
(AD). It results in mental symptoms including behavioral abnormalities and cognitive …

In Vitro and In Silico Evaluation of Anticholinesterase and Antidiabetic Effects of Furanolabdanes and Other Constituents from Graptophyllum pictum (Linn.) Griffith

NT Metiefeng, AN Tamfu, M Fotsing Tagatsing… - Molecules, 2023 - mdpi.com
Graptophyllum pictum is a tropical plant noticeable for its variegated leaves and exploited for
various medicinal purposes. In this study, seven compounds, including three furanolabdane …

Medicinal herbs and their derived ingredients protect against cognitive decline in in vivo models of Alzheimer's disease

YT Tsai, ST Kao, CY Cheng - International Journal of Molecular Sciences, 2022 - mdpi.com
Alzheimer's disease (AD) has pathological hallmarks including amyloid beta (Aβ) plaque
formation. Currently approved single-target drugs cannot effectively ameliorate AD …

[HTML][HTML] An overview of structure-based activity outcomes of pyran derivatives against Alzheimer's disease

FA Almalki - Saudi Pharmaceutical Journal, 2023 - Elsevier
Pyran is a heterocyclic group containing oxygen that possesses a variety of pharmacological
effects. Pyran is also one of the most prevalent structural subunits in natural products, such …

[HTML][HTML] Recent advances in brain delivery of synthetic and natural nano therapeutics: Reviving hope for Alzheimer's disease patients

DS Nady, U Bakowsky, SA Fahmy - Journal of Drug Delivery Science and …, 2023 - Elsevier
As the globe's population increases, the incidences of Alzheimer's disease (AD) are steadily
increasing. AD represents the most common neurological disorder and constitutes 60–70 …

[HTML][HTML] Enhancement of Cognitive Function by Andrographolide-Loaded Lactose β-Cyclodextrin Nanoparticles: Synthesis, Optimization, and Behavioural …

D Paramanick, KN Rani, VK Singh, P Basist, R Khan… - Pharmaceuticals, 2024 - mdpi.com
This study investigates whether Andrographolide-loaded Lactose β-Cyclodextrin (ALN-βCD)
nanoparticles enhance cognitive function, particularly spatial learning and memory. The …

Novel Strategy for Alzheimer's Disease Treatment through Oral Vaccine Therapy with Amyloid Beta

Y Matsuzaka, R Yashiro - Biologics, 2023 - mdpi.com
Alzheimer's disease (AD) is a neuropathology characterized by progressive cognitive
impairment and dementia. The disease is attributed to senile plaques, which are aggregates …

Phyto-nanotechnology: A novel beneficial strategy for Alzheimer's disease therapy

SC Ganguly, S Sangram, S Paul, M Kundu - Neurochemistry International, 2024 - Elsevier
Alzheimer's disease, a neurodegenerative condition, is characterized by the slow and
progressive deterioration of the cognitive functions of geriatric patients. It occurs due to …

Green synthesis of nanoparticles using medicinal plants as an eco-friendly and therapeutic potential approach for neurodegenerative diseases: a comprehensive …

R Izadi, S Bahramikia, V Akbari - Frontiers in Neuroscience, 2024 - frontiersin.org
Central nervous system disorders impact over 1.5 billion individuals globally, with
neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's diseases …