M Kuro-o - Nature Reviews Nephrology, 2019 - nature.com
Abstract The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity …
A Gyenis, J Chang, JJPG Demmers, ST Bruens… - Nature …, 2023 - nature.com
Gene expression profiling has identified numerous processes altered in aging, but how these changes arise is largely unknown. Here we combined nascent RNA sequencing and …
Biological aging is associated with a reduction in the reparative and regenerative potential in tissues and organs. This reduction manifests as a decreased physiological reserve in …
JA Marteijn, H Lans, W Vermeulen… - … reviews Molecular cell …, 2014 - nature.com
Nucleotide excision repair (NER) eliminates various structurally unrelated DNA lesions by a multiwise'cut and patch'-type reaction. The global genome NER (GG-NER) subpathway …
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for …
Obesity has become a major public health problem. Given the current increase in life expectancy, the prevalence of obesity also raises steadily among older age groups. The …
World population has been continuously increasing and progressively aging. Aging is characterized by a complex and intraindividual process associated with nine major cellular …
JHJ Hoeijmakers - New England Journal of Medicine, 2009 - Mass Medical Soc
This review gives an account of how the cell repairs DNA damage and presents evidence that DNA damage contributes to aging and cancer, with the outcome dependent on the type …
Stem cell aging and exhaustion are considered important drivers of organismal aging. Age- associated declines in stem cell function are characterized by metabolic and epigenetic …