A large number of structurally diverse natural compounds containing azole nucleus
constitute an important class of biologically active heterocycles that are gaining more …

In the recent past trifluoromethylpyrazoles have gained much attention, particularly as anti-
inflammatory and antibacterial agents, in the field of medicinal chemistry. The location of …

A transition-metal-free [3+ 2] cycloaddition between trifluoroacetaldehyde N-
triftosylhydrazone (TFHZ-Tfs) and alkynes is reported. This protocol provides an …

There is an urgent need for new antibiotics and alternative strategies to combat multidrug-
resistant bacterial pathogens, which are a growing clinical issue. Repurposing existing …

Angiogenesis is a mulit-step process by which new blood vessels are formed from
preexisting vasculature. It is a key rate limiting factor in tumor growth since new blood …

Isoxazoline and isoxazole derivatives are an important class of nitrogen and oxygen
containing heterocycles that are well known to display an array of various biological …

In continuation of our efforts to find new biologically active agents, regioselective synthesis
of a series of 2-(3, 5-dimethyl-1H-pyrazol-1-yl)-1-arylethanones 4a–k has been achieved …

A series of new sulfonamides have been synthesized from Ampyrone with different benzene
sulfonyl chlorides to yield the N-1, 5-dimethyl-3-oxo-2-phenyl-2, 3-dihydro-1 H-pyrazol-4-yl) …

Cyclooxygenase-2 (COX-2) is implicated in the development of chronic inflammatory
diseases. Recently, pyridazine derivatives have emerged as a novel prototype to develop …

The present work was conducted to examine whether celecoxib, a selective COX-2 inhibitor,
200 mg administered 1 h preoperatively to patients undergoing arthroscopic hip surgery …