Cannabis and synaptic reprogramming of the developing brain

A Bara, JMN Ferland, G Rompala, H Szutorisz… - Nature Reviews …, 2021 - nature.com
Recent years have been transformational in regard to the perception of the health risks and
benefits of cannabis with increased acceptance of use. This has unintended …

Cellular senescence in neurodegenerative diseases

C Martínez-Cué, N Rueda - Frontiers in cellular neuroscience, 2020 - frontiersin.org
Cellular senescence is a homeostatic biological process characterized by a permanent state
of cell cycle arrest that can contribute to the decline of the regenerative potential and …

Astrocytes and major depression: The purinergic avenue

YF Zhao, A Verkhratsky, Y Tang, P Illes - Neuropharmacology, 2022 - Elsevier
Major depressive disorder (MDD) is one of the most prevalent psychiatric illnesses
worldwide which impairs the social functioning of the afflicted patients. Astrocytes promote …

N6-methyladenosine and neurological diseases

N Zhang, C Ding, Y Zuo, Y Peng, L Zuo - Molecular neurobiology, 2022 - Springer
Abstract N6-methyladenosine (m6A) is a dynamic reversible methylation modification of the
adenosine N6 position and is the most common chemical epigenetic modification among …

[HTML][HTML] Role of TET1-mediated epigenetic modulation in Alzheimer's disease

MJ Armstrong, Y Jin, SM Vattathil, Y Huang… - Neurobiology of …, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder influenced by a complex interplay
of environmental, epigenetic, and genetic factors. DNA methylation (5mC) and …

DNA methylation: a promising approach in management of Alzheimer's disease and other neurodegenerative disorders

G Kaur, SSS Rathod, MM Ghoneim, S Alshehri… - Biology, 2022 - mdpi.com
Simple Summary DNA methylation is an epigenetic modification of genes which affects
corresponding gene expression. During the developmental stage, embryonic stem cells …

One-carbon epigenetics and redox biology of neurodegeneration

F Coppedè - Free Radical Biology and Medicine, 2021 - Elsevier
One-carbon metabolism provides the methyl groups for both DNA and histone tail
methylation reactions, two of the main epigenetic processes that tightly regulate the …

MuLan-Methyl—multiple transformer-based language models for accurate DNA methylation prediction

W Zeng, A Gautam, DH Huson - GigaScience, 2023 - academic.oup.com
Transformer-based language models are successfully used to address massive text-related
tasks. DNA methylation is an important epigenetic mechanism, and its analysis provides …

[HTML][HTML] Epigenetic regulation of neuroinflammation in Alzheimer's Disease

Y Ma, W Wang, S Liu, X Qiao, Y Xing, Q Zhou, Z Zhang - Cells, 2023 - mdpi.com
Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disease and
clinically manifests with cognitive decline and behavioral disabilities. Over the past years …

Epigenomic and enhancer dysregulation in uterine leiomyomas

OW Mlodawska, P Saini, JB Parker… - Human …, 2022 - academic.oup.com
BACKGROUND Uterine leiomyomas, also known as uterine fibroids or myomas, are the
most common benign gynecological tumors and are found in women of reproductive and …