Cytokinesis, the final step in cell division, partitions the contents of a single cell into two. In
animal cells, cytokinesis occurs through cortical remodeling orchestrated by the anaphase …

Aurora is the name given to a family of highly conserved protein kinases with essential roles
in many aspects of cell division. Yeasts have a single Aurora kinase, whereas mammals …

Kinesins are a family of molecular motors that use the energy of ATP hydrolysis to move
along the surface of, or destabilize, microtubule filaments. Much progress has been made in …

Neuroblastoma is the most common extracranial solid tumor of children. Neuroblastoma
tumors derive from the neural crest and synthesize neurotransmitters including the …

Mitosis and meiosis are remarkable processes during which cells undergo profound
changes in their structure and physiology. These events are orchestrated with a precision …

The three human homologues of Aurora kinases (A, B and C) are essential for proper
execution of various mitotic events and are important for maintaining genomic integrity …

Phosphorylation at a highly conserved serine residue (Ser-10) in the histone H3 tail is
considered to be a crucial event for the onset of mitosis. This modification appears early in …

After anaphase onset, animal cells build an actomyosin contractile ring that constricts the
plasma membrane to generate two daughter cells connected by a cytoplasmic bridge. The …

Aurora/Ipl1-related kinases are a conserved family of enzymes that have multiple functions
during mitotic progression. Although it has been possible to use conventional genetic …

A late step in cytokinesis requires the central spindle, which forms during anaphase by the
bundling of antiparallel nonkinetochore microtubules. Microtubule bundling and completion …