The M1/M2 macrophage paradigm plays a key role in tumor progression. M1 macrophages
are historically regarded as anti-tumor, while M2-polarized macrophages, commonly …

Innate and adaptive immune cells patrol and survey throughout the human body and
sometimes reside in the tumor microenvironment (TME) with a variety of cell types and …

Among mammary tumor-infiltrating immune cells, the highest expression of podoplanin
(PDPN) is found in a subset of tumor-associated macrophages (TAMs). We hereby …

The tumor-draining lymph nodes (TDLNs) are the primary sites of the development of anti-
tumor immunity. Primary tumor irradiation promotes 'radio-vaccination'by enhancing the …

Tumor microenvironment consists of malignant and non-malignant cells. The interaction of
these dynamic and different cells is responsible for tumor progression at different levels. The …

Hepatocellular carcinoma (HCC) is one of the cancers that seriously threaten human health.
Immunotherapy serves as the mainstay of treatment for HCC patients by targeting the …

Fibrocytes are hematopoietic-derived cells that directly contribute to tissue fibrosis by
producing collagen following injury, during disease, and with aging. The lack of a fibrocyte …

Tumor‑associated macrophages (TAMs) are crucial cells of the tumor microenvironment
(TME), which belong to the innate immune system and regulate primary tumor growth …

Purpose Malignant pleural effusion (MPE) is an adverse prognostic factor in patients with
osteoblastic osteosarcoma; however, the cellular contexts of MPE are largely unknown …

Circulating monocytes are a major source of tumor-associated macrophages (TAMs). TAMs
in human breast cancer (BC) support primary tumor growth and metastasis. Neoadjuvant …