[HTML][HTML] GLP-1 and GIP receptor signaling in beta cells–a review of receptor interactions and co-stimulation
A Mayendraraj, MM Rosenkilde, LS Gasbjerg - Peptides, 2022 - Elsevier
Glucagon-like peptide 1 receptor (GLP-1R) and glucose-dependent insulinotropic
polypeptide receptor (GIPR) are two class B1 G protein-coupled receptors, which are …
polypeptide receptor (GIPR) are two class B1 G protein-coupled receptors, which are …
Targeting VIP and PACAP receptor signaling: new insights into designing drugs for the PACAP subfamily of receptors
Pituitary Adenylate Cyclase-Activating Peptide (PACAP) and Vasoactive Intestinal Peptide
(VIP) are neuropeptides involved in a diverse array of physiological and pathological …
(VIP) are neuropeptides involved in a diverse array of physiological and pathological …
Effects of site-directed mutagenesis of GLP-1 and glucagon receptors on signal transduction activated by dual and triple agonists
S Darbalaei, R Chang, Q Zhou, Y Chen, A Dai… - Acta Pharmacologica …, 2023 - nature.com
The paradigm of one drug against multiple targets, known as unimolecular
polypharmacology, offers the potential to improve efficacy while overcoming some adverse …
polypharmacology, offers the potential to improve efficacy while overcoming some adverse …
Molecular basis of signal transduction mediated by the human GIPR splice variants
F Zhao, K Hang, Q Zhou, L Shao, H Li… - Proceedings of the …, 2023 - National Acad Sciences
Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a potential drug target for
metabolic disorders. It works with glucagon-like peptide-1 receptor and glucagon receptor in …
metabolic disorders. It works with glucagon-like peptide-1 receptor and glucagon receptor in …
Tirzepatide, GIP (1-42) and GIP (1-30) display unique signaling profiles at two common GIP receptor variants, E354 and Q354
Type 2 diabetes (T2D) and obesity are prevalent metabolic disorders affecting millions of
individuals worldwide. A new effective therapeutic drug called tirzepatide for the treatment of …
individuals worldwide. A new effective therapeutic drug called tirzepatide for the treatment of …
The activation of gastric inhibitory peptide/gastric inhibitory peptide receptor axis via sonic hedgehog signaling promotes the bridging of gapped nerves in sciatic …
T Guan, B Guo, W Zhang, M Qi, X Luo… - Journal of …, 2023 - Wiley Online Library
Schwann cells play an essential role in peripheral nerve regeneration by generating a
favorable microenvironment. Gastric inhibitory peptide/gastric inhibitory peptide receptor …
favorable microenvironment. Gastric inhibitory peptide/gastric inhibitory peptide receptor …