Vaccines were initially developed on an empirical basis, relying mostly on attenuation or
inactivation of pathogens. Advances in immunology, molecular biology, biochemistry …

Trypanosoma cruzi is the etiologic agent of Chagas disease, a neglected tropical disease
that affects millions of people mainly in Latin America. To establish a life-long infection, T …

Chagas disease is currently endemic to 21 Latin-American countries and has also become a
global concern because of globalization and mass migration of chronically infected …

In the past ten years, studies have shown the recognition of Trypanosoma cruzi‐associated
molecular patterns by members of the Toll‐like receptor (TLR) family and demonstrated the …

Vaccines against parasites have lagged centuries behind those against viral and bacterial
infections, despite the devastating morbidity and widespread effects of parasitic diseases …

The Trypanosomatidae family includes the genera Trypanosoma and Leishmania,
protozoan parasites displaying complex digenetic life cycles requiring a vertebrate host and …

The parasite Trypanosoma cruzi is the causative agent of Chagas disease, a potentially life-
threatening infection that represents a major health problem in Latin America. Several …

Chagas' disease is caused by the protozoan Trypanosoma cruzi, described in the early 20th
century by the Brazilian physician Dr. Carlos Chagas. There was a great amount of research …

Chagas' disease is a major public health problem affecting nearly 10 million in Latin
America. Despite several experimental vaccines have shown to be immunogenic and …

Abstract Immunization with the Amastigote Surface Protein-2 (ASP-2) and Trans-sialidase
(TS) antigens either in the form of recombinant protein, encoded in plasmids or human …