Exploration of CviR-mediated quorum sensing inhibitors from Cladosporium spp. against Chromobacterium violaceum through computational studies
M Murali, F Ahmed, HG Gowtham, JO Aribisala… - Scientific Reports, 2023 - nature.com
An opportunistic human pathogenic bacterium, Chromobacterium violaceum resists the
potency of most antibiotics by exploiting the quorum sensing system within their community …
potency of most antibiotics by exploiting the quorum sensing system within their community …
Phyto‐therapeutic potential of Withania somnifera: Molecular mechanism and health implications
Withania somnifera, the plant named Indian ginseng, Ashwagandha, or winter cherry, has
been used since ancient times to cure various health ailments. Withania somnifera is rich in …
been used since ancient times to cure various health ailments. Withania somnifera is rich in …
In Silico Computational Studies of Bioactive Secondary Metabolites from Wedelia trilobata against Anti-Apoptotic B-Cell Lymphoma-2 (Bcl-2) Protein Associated with …
HG Gowtham, F Ahmed, S Anandan, CS Shivakumara… - Molecules, 2023 - mdpi.com
In the present study, the binding affinity of 52 bioactive secondary metabolites from Wedelia
trilobata towards the anti-apoptotic B-cell lymphoma-2 (Bcl-2) protein (PDB: 2W3L) structure …
trilobata towards the anti-apoptotic B-cell lymphoma-2 (Bcl-2) protein (PDB: 2W3L) structure …
Integration of computational docking into anti-cancer drug response prediction models
Simple Summary Anti-cancer drug response prediction models aim to reduce the time
necessary for developing a treatment for patients affected by this complex disease. Their …
necessary for developing a treatment for patients affected by this complex disease. Their …
Exploration of anti-HIV phytocompounds against SARS-CoV-2 main protease: Structure-based screening, molecular simulation, ADME analysis and conceptual DFT …
M Murali, HG Gowtham, N Shilpa, HKN Krishnappa… - Molecules, 2022 - mdpi.com
The ever-expanding pandemic severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) infection has gained attention as COVID-19 and caused an emergency in public …
CoV-2) infection has gained attention as COVID-19 and caused an emergency in public …
[HTML][HTML] Identification and Assessment of Secondary Metabolites from Three Fungal Endophytes of Solanum mauritianum Against Public Health Pathogens
Fungal endophytes, symbiotic microorganisms residing within plants, are renowned for
producing bioactive secondary metabolites with diverse beneficial properties. We …
producing bioactive secondary metabolites with diverse beneficial properties. We …
An update on existing therapeutic options and status of novel anti-metastatic agents in breast cancer: Elucidating the molecular mechanisms underlying the pleiotropic …
Major significant advancements in pharmacology and drug technology have been made to
heighten the impact of cancer therapies, improving the life expectancy of subjects diagnosed …
heighten the impact of cancer therapies, improving the life expectancy of subjects diagnosed …
Secondary metabolites of Trichoderma spp. as EGFR tyrosine kinase inhibitors: Evaluation of anticancer efficacy through computational approach
HG Gowtham, PD Revanasiddappa, M Murali… - Plos one, 2024 - journals.plos.org
The present study explores the epidermal growth factor receptor (EGFR) tyrosine kinase
inhibition efficacy of secondary metabolites in Trichoderma spp. through molecular docking …
inhibition efficacy of secondary metabolites in Trichoderma spp. through molecular docking …
Pharmacoinformatics approach for the screening of Kovidra (Bauhinia variegata) phytoconstituents against tumor suppressor protein in triple negative breast cancer
P More-Adate, KB Lokhande… - Journal of …, 2024 - Taylor & Francis
Abstract Globally, 2.3 million women were diagnosed with breast cancer, with 6, 85000
mortalities in year 2021; making it the world's most prevalent cancer. This growing global …
mortalities in year 2021; making it the world's most prevalent cancer. This growing global …
Unlocking the potential of approved drugs for the allosteric inhibition of tropomyosin-receptor kinase A using molecular docking and molecular dynamics studies
RM Mukhtar, N Abdelmoniem, HA Elrufaie… - Frontiers in …, 2023 - frontiersin.org
Tropomyosin-receptor kinase A (TrkA) is the primary isoform among the tropomyosin-
receptor kinases that have been associated with human cancer development, contributing to …
receptor kinases that have been associated with human cancer development, contributing to …