In contrast to nitric oxide, which has well established and important roles in the regulation of
blood flow and thrombosis, neurotransmission, the normal functioning of the genitourinary …

Background Recent studies have suggested that cardiac nitrosative stress mediated by
pathological overproduction of nitric oxide (NO) via inducible NO synthase (iNOS) …

Background Recent guidelines recommend riociguat, a soluble guanylate cyclase (sGC)
stimulator, and the type 5 phosphodiesterase inhibitor (PDE5i) tadalafil or sildenafil as …

Endothelial dysfunction is associated with decreased NO bioavailability and impaired
activation of the NO receptor soluble guanylate cyclase (sGC) in the vasculature and in …

Blood‐contacting medical devices routinely fail from the cascading effects of biofouling
toward infection and thrombosis. Nitric oxide (NO) is an integral part of endothelial …

Dietary NO3−(nitrate) and NO2−(nitrite) support˙ NO (nitric oxide) generation and
downstream vascular signaling responses. These nitrogen oxides also generate secondary …

Nitric oxide, NO, has been explored as a therapeutic agent to treat thrombosis. In particular,
NO has potential in treating mechanical device-associated thrombosis due to its ability to …

Objective The role of inhaled nitric oxide in the treatment of shock remains controversial and
further translational research is needed. Long-term observation studies using a model of …

Pulmonary hypertension is a life-threatening complication in β-thalassemia. Inhaled sodium
nitrite has vasodilatory effect on pulmonary vasculature. However, its effect on pulmonary …

Inhaled sodium nitrite has been reported to decrease pulmonary artery pressure in
hemoglobin E/β-thalassemia (HbE/β-thal) patients with pulmonary hypertension. This study …