Cytosolic pH controls fungal MAPK signaling and pathogenicity
Mitogen-activated protein kinases (MAPKs) regulate a variety of cellular processes in
eukaryotes. In fungal pathogens, conserved MAPK pathways control key virulence functions …
eukaryotes. In fungal pathogens, conserved MAPK pathways control key virulence functions …
[HTML][HTML] Phosphatidic acid inhibits inositol synthesis by inducing nuclear translocation of kinase IP6K1 and repression of myo-inositol-3-P synthase
Inositol is an essential metabolite that serves as a precursor for structural and signaling
molecules. Although perturbation of inositol homeostasis has been implicated in numerous …
molecules. Although perturbation of inositol homeostasis has been implicated in numerous …
Valproate regulates inositol synthesis by reducing expression of myo-inositol-3-phosphate synthase
Inositol depletion is a hypothesized mechanism of action of mood stabilization drugs used in
the treatment of bipolar disorder. It was previously reported that the mood stabilizer …
the treatment of bipolar disorder. It was previously reported that the mood stabilizer …
Regulation of yeast Snf1 (AMPK) by a polyhistidine containing pH sensing module
KJ Simpson-Lavy, M Kupiec - Iscience, 2022 - cell.com
Cellular regulation of pH is crucial for internal biological processes and for the import and
export of ions and nutrients. In the yeast Saccharomyces cerevisiae, the major proton pump …
export of ions and nutrients. In the yeast Saccharomyces cerevisiae, the major proton pump …
When Phosphatases Go Mad: The Molecular Basis for Toxicity of Yeast Ppz1
A Casamayor, J Ariño - International journal of molecular sciences, 2022 - mdpi.com
The fact that overexpression of the yeast Ser/Thr protein phosphatase Ppz1 induces a
dramatic halt in cell proliferation was known long ago, but only work in the last few years has …
dramatic halt in cell proliferation was known long ago, but only work in the last few years has …
Deciphering the intricate role of mTOR signaling and autophagy in Parkinson's disease and therapeutic prospects
L Narayanan, D Thekkekkara… - Journal of Applied …, 2024 - japsonline.com
The mammalian/mechanistic target of rapamycin (mTOR) has a prominent role in many
neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease (PD) …
neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease (PD) …
Phosphatidic acid inhibits inositol synthesis by inducing nuclear translocation of IP6K1 and repression of myo-inositol-3-P synthase
P Lazcano, MW Schmidtke, C Onu, ML Greenberg - bioRxiv, 2022 - biorxiv.org
Inositol is an essential metabolite that serves as a precursor for structural and signaling
molecules. Although perturbation of inositol homeostasis has been implicated in numerous …
molecules. Although perturbation of inositol homeostasis has been implicated in numerous …
Valproate-Induced Inositol Depletion Is a Consequence of Reduced MIPS Expression Mediated by the Henry Regulatory Circuit
KC Case - 2024 - search.proquest.com
Inositol is an essential component of cellular functions. Importantly, de novo synthesis of
inositol accounts for nearly half of the inositol found in the brain. Valproate, a drug used to …
inositol accounts for nearly half of the inositol found in the brain. Valproate, a drug used to …
Cytosolic pH Controls Fungal MAPK Signaling and Pathogenicity
H Martín Brieva, T Fernández-Acero Bascones… - 2023 - docta.ucm.es
Mitogen-activated protein kinases (MAPKs) regulate a variety of cellular processes in
eukaryotes. In fungal pathogens, conserved MAPK pathways control key virulence functions …
eukaryotes. In fungal pathogens, conserved MAPK pathways control key virulence functions …