In the last 25 years, HIV-1, the retrovirus responsible for the acquired immunodeficiency
syndrome (AIDS), has gone from being an “inherently untreatable” infectious agent to one …

Attention-deficit/hyperactivity disorder, ADHD, is a common and highly heritable
neuropsychiatric disorder that is seen in children and adults. Although heritability is …

Coronary artery disease (CAD) is the leading cause of death and disability worldwide, and
its prevalence is expected to increase in the coming years. CAD events are caused by the …

Statins are highly effective drugs prescribed to millions of people to lower LDL-cholesterol
and decrease cardiovascular risk. The benefits of statin therapy seen in randomized clinical …

The large-scale generation and integration of genomic, proteomic, signalling and
metabolomic data are increasingly allowing the construction of complex networks that …

There are several definitions of biomarkers. A biomarker is a characteristic that can be
objectively measured and evaluated as an indicator of a physiological as well as a …

The past decade has seen tremendous advances in our understanding of the genetic factors
influencing response to a variety of drugs, including those targeted at treatment of …

Abstract'Personalized medicine'promises to increase the quality of clinical care and, in some
cases, decrease health-care costs. Despite this, only a handful of diagnostic tests have …

Objective—We asked whether single nucleotide polymorphisms (SNPs) that had been
nominally associated with cardiovascular disease in antecedent studies were also …

We carried out a genome-wide association study (GWAS) of LDL-c response to statin using
data from participants in the Collaborative Atorvastatin Diabetes Study (CARDS; n= 1,156) …