Wound healing, fibroblast heterogeneity, and fibrosis
Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …
However, the mechanisms by which they contribute to both physiologic and pathologic …
Targeting fibrosis: Mechanisms and clinical trials
M Zhao, L Wang, M Wang, S Zhou, Y Lu… - Signal transduction and …, 2022 - nature.com
Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop …
dysregulated wound and connective tissue repair response. Multiple organs can develop …
Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring
INTRODUCTION Skin wounds generally heal by scarring, a fibrotic process mediated by the
Engrailed-1 (En1) fibroblast lineage. Scars differ from normal unwounded skin in three …
Engrailed-1 (En1) fibroblast lineage. Scars differ from normal unwounded skin in three …
Developmental cell programs are co-opted in inflammatory skin disease
G Reynolds, P Vegh, J Fletcher, EFM Poyner… - Science, 2021 - science.org
INTRODUCTION Human skin provides vital protection from water loss and from external
insult through structural adaptations and interplay with the innate and adaptive immune …
insult through structural adaptations and interplay with the innate and adaptive immune …
Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases
CC Deng, YF Hu, DH Zhu, Q Cheng, JJ Gu… - Nature …, 2021 - nature.com
Fibrotic skin disease represents a major global healthcare burden, characterized by
fibroblast hyperproliferation and excessive accumulation of extracellular matrix. Fibroblasts …
fibroblast hyperproliferation and excessive accumulation of extracellular matrix. Fibroblasts …
Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis
The immunopathogenesis of psoriasis, a common chronic inflammatory disease of the skin,
is incompletely understood. Here we demonstrate, using a combination of single cell and …
is incompletely understood. Here we demonstrate, using a combination of single cell and …
The role of myofibroblasts in physiological and pathological tissue repair
Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …
Shared and distinct mechanisms of fibrosis
JHW Distler, AH Györfi, M Ramanujam… - Nature Reviews …, 2019 - nature.com
Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …
Identification, discrimination and heterogeneity of fibroblasts
U Lendahl, L Muhl, C Betsholtz - Nature communications, 2022 - nature.com
Fibroblasts, the principal cell type of connective tissue, secrete extracellular matrix
components during tissue development, homeostasis, repair and disease. Despite this …
components during tissue development, homeostasis, repair and disease. Despite this …
Single cell transcriptomic landscape of diabetic foot ulcers
Diabetic foot ulceration (DFU) is a devastating complication of diabetes whose pathogenesis
remains incompletely understood. Here, we profile 174,962 single cells from the foot …
remains incompletely understood. Here, we profile 174,962 single cells from the foot …