With the development of heteronuclear fluorine, sodium, phosphorus, and other probes and
imaging technologies as well as the optimization of magnetic resonance imaging (MRI) …

Hyperpolarized carbon‐13 magnetic resonance imaging (HP 13C MRI) is a recently
translated metabolic imaging technique. With dissolution dynamic nuclear polarization (d …

Abstract Hyperpolarized [1-13C] pyruvate enables direct in vivo assessment of real-time liver
enzymatic activities by 13C magnetic resonance. However, the technique usually requires …

Hyperpolarized (HP) 13C magnetic resonance enables non‐invasive probing of metabolism
in vivo. To date, only 13C‐molecules hyperpolarized with persistent trityl radicals have been …

Purpose This study is to investigate time‐resolved 13C MR spectroscopy (MRS) as an
alternative to imaging for assessing pyruvate metabolism using hyperpolarized (HP)[1‐13C] …

The feasibility of hyperpolarized [2-13C, 3-2H3] pyruvate for probing gluconeogenesis in
vivo was investigated in this study. Whereas hyperpolarized [1-13C] pyruvate has clear …

Hyperpolarized 13C nuclear magnetic resonance spectroscopy can characterize in vivo
tissue metabolism, including preclinical models of cancer and inflammatory disease. Broad …

The liver is a key node of whole-body nutrient and fuel metabolism and is also the principal
site for detoxification of xenobiotic compounds. As such, hepatic metabolite concentrations …

In a clinical setting, ex vivo perfusions are routinely used to maintain and assess organ
viability prior to transplants. Organ perfusions are also a model system to examine metabolic …

Purpose Hyperpolarized [1‐13C] pyruvate MRI is an emerging clinical tool for metabolic
imaging. It has the potential for absolute quantitative metabolic imaging. However, the …