The role of inflammation in cardiovascular disease

MY Henein, S Vancheri, G Longo… - International journal of …, 2022 - mdpi.com
Atherosclerosis is a chronic inflammatory disease, in which the immune system has a
prominent role in its development and progression. Inflammation-induced endothelial …

[HTML][HTML] Effects of COVID-19 on the nervous system

C Iadecola, J Anrather, H Kamel - Cell, 2020 - cell.com
Neurological complications have emerged as a significant cause of morbidity and mortality
in the ongoing COVID-19 pandemic. Beside respiratory insufficiency, many hospitalized …

Immune responses to stroke: mechanisms, modulation, and therapeutic potential

C Iadecola, MS Buckwalter… - The Journal of clinical …, 2020 - Am Soc Clin Investig
Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …

The association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and lymphocyte to monocyte ratio with post-thrombolysis early neurological outcomes in …

P Gong, Y Liu, Y Gong, G Chen, X Zhang… - Journal of …, 2021 - Springer
Background and purpose To investigate the association of neutrophil to lymphocyte ratio
(NLR), platelet to lymphocyte ratio (PLR), and lymphocyte to monocyte ratio (LMR) with post …

Neuroinflammation in acute ischemic and hemorrhagic stroke

DL Alsbrook, M Di Napoli, K Bhatia, J Biller… - Current neurology and …, 2023 - Springer
Abstract Purpose of Review This review aims to provide an overview of neuroinflammation
in ischemic and hemorrhagic stroke, including recent findings on the mechanisms and …

Gut microbiome-mediated regulation of neuroinflammation

JW Bostick, AM Schonhoff, SK Mazmanian - Current opinion in immunology, 2022 - Elsevier
Highlights•Microbe-derived molecules influence disease outcomes through diverse
mechanisms.•Short-chain fatty acid (SCFA) production in the gut can alter microglial …

Monocyte-derived IL-6 programs microglia to rebuild damaged brain vasculature

BR Choi, KR Johnson, D Maric, DB McGavern - Nature immunology, 2023 - nature.com
Cerebrovascular injury (CVI) is a common pathology caused by infections, injury, stroke,
neurodegeneration and autoimmune disease. Rapid resolution of a CVI requires a …

Filling the gaps on stroke research: Focus on inflammation and immunity

D Levard, I Buendia, A Lanquetin, M Glavan… - Brain, behavior, and …, 2021 - Elsevier
For the last two decades, researchers have placed hopes in a new era in which a
combination of reperfusion and neuroprotection would revolutionize the treatment of stroke …

Statin therapy and outcome after ischemic stroke: systematic review and meta-analysis of observational studies and randomized trials

D Ní Chróinín, K Asplund, S Åsberg, E Callaly… - Stroke, 2013 - Am Heart Assoc
Background and Purpose—Although experimental data suggest that statin therapy may
improve neurological outcome after acute cerebral ischemia, the results from clinical studies …

Thiophene-based compounds with potential anti-inflammatory activity

RMD da Cruz, FJB Mendonça-Junior, NB de Mélo… - Pharmaceuticals, 2021 - mdpi.com
Rheumatoid arthritis, arthrosis and gout, among other chronic inflammatory diseases are
public health problems and represent major therapeutic challenges. Non-steroidal anti …