Intracellular cAMP sensor EPAC: physiology, pathophysiology, and therapeutics development
WG Robichaux III, X Cheng - Physiological reviews, 2018 - journals.physiology.org
This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …
Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions
Since the discovery nearly 60 years ago, cAMP is envisioned as one of the most universal
and versatile second messengers. The tremendous feature of cAMP to tightly control highly …
and versatile second messengers. The tremendous feature of cAMP to tightly control highly …
Paving the Rho in cancer metastasis: Rho GTPases and beyond
Malignant carcinomas are often characterized by metastasis, the movement of carcinoma
cells from a primary site to colonize distant organs. For metastasis to occur, carcinoma cells …
cells from a primary site to colonize distant organs. For metastasis to occur, carcinoma cells …
A protein fold switch joins the circadian oscillator to clock output in cyanobacteria
Organisms are adapted to the relentless cycles of day and night, because they evolved
timekeeping systems called circadian clocks, which regulate biological activities with~ 24 …
timekeeping systems called circadian clocks, which regulate biological activities with~ 24 …
Cyclic AMP sensor EPAC proteins and their role in cardiovascular function and disease
F Lezoualc'h, L Fazal, M Laudette, C Conte - Circulation research, 2016 - Am Heart Assoc
cAMP is a universal second messenger that plays central roles in cardiovascular regulation
influencing gene expression, cell morphology, and function. A crucial step toward a better …
influencing gene expression, cell morphology, and function. A crucial step toward a better …
Targeting the small GTPase superfamily through their regulatory proteins
The Ras superfamily of small GTPases are guanine‐nucleotide‐dependent switches
essential for numerous cellular processes. Mutations or dysregulation of these proteins are …
essential for numerous cellular processes. Mutations or dysregulation of these proteins are …
Motor learning requires Purkinje cell synaptic potentiation through activation of AMPA-receptor subunit GluA3
N Gutierrez-Castellanos, CM Da Silva-Matos, K Zhou… - Neuron, 2017 - cell.com
Accumulating evidence indicates that cerebellar long-term potentiation (LTP) is necessary
for procedural learning. However, little is known about its underlying molecular mechanisms …
for procedural learning. However, little is known about its underlying molecular mechanisms …
Biochemical and pharmacological characterizations of ESI-09 based EPAC inhibitors: defining the ESI-09 “therapeutic window”
The cAMP signaling cascade is one of the most frequently targeted pathways for the
development of pharmaceutics. A plethora of recent genetic and pharmacological studies …
development of pharmaceutics. A plethora of recent genetic and pharmacological studies …
Efficient Golgi forward trafficking requires GOLPH3-driven, PI4P-dependent membrane curvature
Vesicle budding for Golgi-to-plasma membrane trafficking is a key step in secretion. Proteins
that induce curvature of the Golgi membrane are predicted to be required, by analogy to …
that induce curvature of the Golgi membrane are predicted to be required, by analogy to …
Genetically encoded fluorescent biosensors for live-cell visualization of protein phosphorylation
Fluorescence-based, genetically encodable biosensors are widely used tools for real-time
analysis of biological processes. Over the last few decades, the number of available …
analysis of biological processes. Over the last few decades, the number of available …