HLA‐G immune modulatory genes and molecules are presently being studied by a
widespread number of research groups. In the present study, we do not aim to be exhaustive …

Allergy is an inflammatory process determined by a cascade of immune events
characterized by T-helper 2 lymphocytes polarization leading to interleukin-4 upregulation …

Although chronic spontaneous urticaria (CSU) is a common disease, GWASs of CSU are
lacking. We aimed to identify susceptibility SNPs by performing a GWAS in Chinese Han …

HLA-G is a promiscuous immune checkpoint molecule. The HLA-G gene presents
substantial nucleotide variability in its regulatory regions. However, it encodes a limited …

Despite major improvements in diagnostics and therapy in early as well as in locally
advanced breast cancer (LABC), metastatic relapse occurs in about 20% of patients, often …

Sexual dimorphism in prevalence, severity and genetic susceptibility exists for most common
diseases. However, most genetic and clinical outcome studies are designed in sex …

The allergic asthma phenotype is characterized by a T helper type 2 (Th2) immune
response, based on Immunoglobulin E (IgE)-mediated type 1 hypersensitivity reactions …

Human leukocyte antigens (HLA) are significant genetic risk factors in a long list of diseases.
However, the mechanisms underlying these associations remain elusive in many cases. The …

Background Patients' inflammatory history is an important factor underlying red blood cell
(RBC) alloimmunization, which is a frequent transfusion complication among individuals …

Human leukocyte antigen (HLA)-G is an immune checkpoint molecule that is highly
expressed in papillary thyroid carcinoma (PTC). The HLA-G gene presents several …