Horizontal gene transfer of antibiotic resistance genes in biofilms

C Michaelis, E Grohmann - Antibiotics, 2023 - mdpi.com
Most bacteria attach to biotic or abiotic surfaces and are embedded in a complex matrix
which is known as biofilm. Biofilm formation is especially worrisome in clinical settings as it …

Quinolones: mechanism, lethality and their contributions to antibiotic resistance

NG Bush, I Diez-Santos, LR Abbott, A Maxwell - Molecules, 2020 - mdpi.com
Fluoroquinolones (FQs) are arguably among the most successful antibiotics of recent times.
They have enjoyed over 30 years of clinical usage and become essential tools in the …

[HTML][HTML] Antibiotics for cancer treatment: A double-edged sword

Y Gao, Q Shang, W Li, W Guo, A Stojadinovic… - Journal of …, 2020 - ncbi.nlm.nih.gov
Various antibiotics have been used in the treatment of cancers, via their anti-proliferative,
pro-apoptotic and anti-epithelial-mesenchymal-transition (EMT) capabilities. However …

Ct values from SARS-CoV-2 diagnostic PCR assays should not be used as direct estimates of viral load

E Dahdouh, F Lázaro-Perona… - Journal of …, 2021 - journalofinfection.com
The model is a discretized version of a Susceptible Infectious and Recovered (SIR)-type
model 7 We have set R0= 1. 17 based on current data in our area. 8 We estimated the initial …

Evolutionary rationale for phages as complements of antibiotics

C Torres-Barceló, ME Hochberg - Trends in microbiology, 2016 - cell.com
Antibiotic-resistant bacterial infections are a major concern to public health. Phage therapy
has been proposed as a promising alternative to antibiotics, but an increasing number of …

Bacteriophages Contribute to the Spread of Antibiotic Resistance Genes among Foodborne Pathogens of the Enterobacteriaceae Family – A Review

A Colavecchio, B Cadieux, A Lo… - Frontiers in …, 2017 - frontiersin.org
Foodborne illnesses continue to have an economic impact on global health care systems.
There is a growing concern regarding the increasing frequency of antibiotic resistance in …

Plasmid-mediated transfer of antibiotic resistance genes in soil

M Meng, Y Li, H Yao - Antibiotics, 2022 - mdpi.com
Due to selective pressure from the widespread use of antibiotics, antibiotic resistance genes
(ARGs) are found in human hosts, plants, and animals and virtually all natural environments …

Bacteriophage-mediated horizontal gene transfer: transduction

CL Schneider - Bacteriophages: biology, technology, therapy, 2021 - Springer
Horizontal gene transfer (HGT) can create tremendous genetic diversity in organisms,
especially those which reproduce asexually. The three classical mechanisms for HGT in …

Inflammation boosts bacteriophage transfer between Salmonella spp.

M Diard, E Bakkeren, JK Cornuault, K Moor… - Science, 2017 - science.org
Bacteriophage transfer (lysogenic conversion) promotes bacterial virulence evolution. There
is limited understanding of the factors that determine lysogenic conversion dynamics within …

From Petri Dishes to Patients to Populations: Scales and Evolutionary Mechanisms Driving Antibiotic Resistance

C Souque, I González Ojeda… - Annual Review of …, 2024 - annualreviews.org
Tackling the challenge created by antibiotic resistance requires understanding the
mechanisms behind its evolution. Like any evolutionary process, the evolution of …