The different shades of fat

V Peirce, S Carobbio, A Vidal-Puig - Nature, 2014 - nature.com
Our understanding of adipose tissue biology has progressed rapidly since the turn of the
century. White adipose tissue has emerged as a key determinant of healthy metabolism and …

Adipocyte differentiation from the inside out

ED Rosen, OA MacDougald - Nature reviews Molecular cell biology, 2006 - nature.com
Improved knowledge of all aspects of adipose biology will be required to counter the
burgeoning epidemic of obesity. Interest in adipogenesis has increased markedly over the …

PRDM16 controls a brown fat/skeletal muscle switch

P Seale, B Bjork, W Yang, S Kajimura, S Chin, S Kuang… - Nature, 2008 - nature.com
Brown fat can increase energy expenditure and protect against obesity through a
specialized program of uncoupled respiration. Here we show by in vivo fate mapping that …

Adipocytes as regulators of energy balance and glucose homeostasis

ED Rosen, BM Spiegelman - Nature, 2006 - nature.com
Adipocytes have been studied with increasing intensity as a result of the emergence of
obesity as a serious public health problem and the realization that adipose tissue serves as …

Ten putative contributors to the obesity epidemic

EJ McAllister, NV Dhurandhar, SW Keith… - Critical reviews in …, 2009 - Taylor & Francis
The obesity epidemic is a global issue and shows no signs of abating, while the cause of
this epidemic remains unclear. Marketing practices of energy-dense foods and institutionally …

Differential role of adipose tissues in obesity and related metabolic and vascular complications

A Gómez-Hernández, N Beneit… - International journal …, 2016 - Wiley Online Library
This review focuses on the contribution of white, brown, and perivascular adipose tissues to
the pathophysiology of obesity and its associated metabolic and vascular complications …

[HTML][HTML] Developmental origin of fat: tracking obesity to its source

S Gesta, YH Tseng, CR Kahn - Cell, 2007 - cell.com
The development of obesity not only depends on the balance between food intake and
caloric utilization but also on the balance between white adipose tissue, which is the primary …

Autophagy regulates adipose mass and differentiation in mice

R Singh, Y Xiang, Y Wang, K Baikati… - The Journal of …, 2009 - Am Soc Clin Investig
The relative balance between the quantity of white and brown adipose tissue can profoundly
affect lipid storage and whole-body energy homeostasis. However, the mechanisms …

Cellular bioenergetics as a target for obesity therapy

YH Tseng, AM Cypess, CR Kahn - Nature reviews Drug discovery, 2010 - nature.com
Obesity develops when energy intake exceeds energy expenditure. Although most current
obesity therapies are focused on reducing calorific intake, recent data suggest that …

Different adipose depots: their role in the development of metabolic syndrome and mitochondrial response to hypolipidemic agents

B Bjørndal, L Burri, V Staalesen, J Skorve… - Journal of …, 2011 - Wiley Online Library
Adipose tissue metabolism is closely linked to insulin resistance, and differential fat
distributions are associated with disorders like hypertension, diabetes, and cardiovascular …