The Wilms' tumor 1 gene (WT1) has been identified as a tumor suppressor gene involved in
the etiology of Wilms' tumor. Approximately 10% of all Wilms' tumors carry mutations in the …

The following brief summary is based on a recent wx review by Rubin and Baserga 1, and
the reader is referred to that review for extended references. A simplified representation of …

Endometrial stromal tumors are divided into three types: benign stromal nodules,
endometrial stromal sarcomas, and undifferentiated endometrial sarcomas. A variety of …

Desmoplastic small round cell tumor is a rare, aggressive neoplasm that mainly affects
young male patients and is characterized by a reciprocal translocation t (11; 22)(p13; q12) …

Purpose Ganitumab is a fully human monoclonal antibody against type-1 insulin-like growth
factor receptor (IGF1R). An open-label phase II study was conducted to evaluate the efficacy …

Wilms tumor or nephroblastoma is a pediatric kidney cancer arising from pluripotent
embryonic renal precursors. Multiple genetic loci have been linked to Wilms tumorigenesis; …

Insulin-like growth factors were discovered more than 50 years ago as mediators of growth
hormone that effect growth and differentiation of bone and skeletal muscle. Interest of the …

The insulin-like growth factor (IGF-1) signalling is highly implicated in cancer. In this
signalling the IGF-1 receptor (IGF-1R) is unquestionable, the predominating single factor …

The insulin-like growth factor (IGF) system, which is constituted by the IGF-1 and IGF-2
peptide hormones, their corresponding receptors and several IGF binding proteins, is …

Sarcomas are a diverse group of malignant mesenchymal tumours arising from bone and
soft tissues. The identification of critical cellular signalling pathways in sarcomas is an …