Immunomodulation by radiotherapy in tumour control and normal tissue toxicity

UM Cytlak, DP Dyer, J Honeychurch… - Nature Reviews …, 2022 - nature.com
Radiotherapy (RT) is a highly effective anticancer treatment that is delivered to more than
half of all patients with cancer. In addition to the well-documented direct cytotoxic effects, RT …

Mucositis: pathobiology and management

A Villa, ST Sonis - Current opinion in oncology, 2015 - journals.lww.com
Oral mucositis is a common complication of cancer treatment that may negatively impact the
patient's cancer treatment outcome. Despite its frequency and consequences, the lack of …

Radioprotection and radiomitigation: from the bench to clinical practice

E Obrador, R Salvador, JI Villaescusa, JM Soriano… - Biomedicines, 2020 - mdpi.com
The development of protective agents against harmful radiations has been a subject of
investigation for decades. However, effective (ideal) radioprotectors and radiomitigators …

Emerging evidence on the pathobiology of mucositis

N Al-Dasooqi, ST Sonis, JM Bowen, E Bateman… - Supportive care in …, 2013 - Springer
Background Considerable progress has been made in our understanding of the biological
basis for cancer therapy-induced mucosal barrier injury (mucositis). The last formal review of …

Mechanisms of inflammatory responses to radiation and normal tissues toxicity: clinical implications

M Najafi, E Motevaseli, A Shirazi, G Geraily… - … journal of radiation …, 2018 - Taylor & Francis
Purpose: Cancer treatment is one of the most challenging diseases in the present era.
Among a few modalities for cancer therapy, radiotherapy plays a pivotal role in more than …

Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients and clinical practice guidelines

A Ariyawardana, KKF Cheng, A Kandwal, V Tilly… - Supportive Care in …, 2019 - Springer
Purpose The aim of this systematic review was to update the clinical practice guidelines for
the use of anti-inflammatory agents in the prevention and/or treatment of oral mucositis …

Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression

AA Alhaider, HM Korashy, MM Sayed-Ahmed… - Chemico-biological …, 2011 - Elsevier
Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting
from defects in insulin secretion and/or action. One of the most important complications of …

Anti‐inflammatory cytokines: important immunoregulatory factors contributing to chemotherapy‐induced gastrointestinal mucositis

M Sultani, AM Stringer, JM Bowen… - … research and practice, 2012 - Wiley Online Library
“Mucositis” is the clinical term used to describe ulceration and damage of the mucous
membranes of the entire gastrointestinal tract (GIT) following cytotoxic cancer chemotherapy …

Melatonin protects rats from radiotherapy-induced small intestine toxicity

B Fernández-Gil, AEA Moneim, F Ortiz, YQ Shen… - PloS one, 2017 - journals.plos.org
Radiotherapy-induced gut toxicity is among the most prevalent dose-limiting toxicities
following radiotherapy. Prevention of radiation enteropathy requires protection of the small …

Implication of nano-antioxidant therapy for treatment of hepatocellular carcinoma using PLGA nanoparticles of rutin

P Pandey, M Rahman, PC Bhatt, S Beg, B Paul… - …, 2018 - Taylor & Francis
Aim: The present work describes the development of poly (lactic co-glycolic acid)(PLGA)
nanoparticles (NPs) of rutin (RT) for the treatment of hepatocellular carcinoma in rats …