Developing powerful, simple and low-cost DNA amplification techniques is of great
significance to bioanalysis and biomedical research. Thus far, many signal amplification …

RNA-fluorescence in situ hybridization (FISH) is a powerful tool to visualize target
messenger RNA transcripts in cultured cells, tissue sections or whole-mount preparations …

In situ hybridization based on the mechanism of the hybridization chain reaction (HCR) has
addressed multi-decade challenges that impeded imaging of mRNA expression in diverse …

Canonical roles for macrophages in mediating the fibrotic response after a heart attack
include extracellular matrix turnover and activation of cardiac fibroblasts to initiate collagen …

The Notch signaling pathway comprises multiple ligands that are used in distinct biological
contexts. In principle, different ligands could activate distinct target programs in signal …

Clonal bacterial populations rely on transcriptional variation across individual cells to
produce specialized states that increase fitness. Understanding all cell states requires …

LY6E is an antiviral restriction factor that inhibits coronavirus spike-mediated fusion, but the
cell types in vivo that require LY6E for protection from respiratory coronavirus infection are …

A wealth of specialized neuroendocrine command systems intercalated within the
hypothalamus control the most fundamental physiological needs in vertebrates …

Internal states of the brain profoundly influence behavior. Fluctuating states such as
alertness can be governed by neuromodulation, but the underlying mechanisms and cell …

The molecular signatures of cells in the brain have been revealed in unprecedented detail,
yet the ageing-associated genome-wide expression changes that may contribute to …