Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …

Runt-related transcription factor 2 (Runx2) is a fundamental transcription factor for bone
development. In endochondral ossification, Runx2 induces chondrocyte maturation …

Loss of skeletal integrity during ageing and disease is associated with an imbalance in the
opposing actions of osteoblasts and osteoclasts. Here we show that intrinsic ageing of …

Vertebral bone is subject to a distinct set of disease processes from long bones, including a
much higher rate of solid tumour metastases,,–. The basis for this distinct biology of vertebral …

Bone is a dynamic tissue constantly responding to environmental changes such as
nutritional and mechanical stress. Bone homeostasis in adult life is maintained through bone …

As a kind of nature-derived bioactive materials, polyphenol-based hydrogels possess many
unique and outstanding properties such as adhesion, toughness, and self-healing due to …

Bone marrow mesenchymal lineage cells are a heterogeneous cell population involved in
bone homeostasis and diseases such as osteoporosis. While it is long postulated that they …

Multiple distinct types of skeletal progenitors have been shown to contribute to
endochondral bone development and maintenance. However, the division of labor and …

Bone marrow stromal cells (BMSCs) are versatile mesenchymal cell populations
underpinning the major functions of the skeleton, a majority of which adjoin sinusoidal blood …

There has been considerable advancement over the last few years in the treatment of
osteoarthritis, common chronic disease and a major cause of disability in older adults. In this …