Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Skeletal muscle is the largest tissue in the body and loss of its function or its regenerative
properties results in debilitating musculoskeletal disorders. Understanding the mechanisms …

We previously demonstrated that long non-coding RNA cytoskeleton regulator RNA
(CYTOR), also known as Linc00152, was significantly overexpressed in colon cancer and …

Wnt signaling executes an indispensable performance in osteoblast differentiation, bone
development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt …

Wnt is a family of signaling molecules involved in embryogenesis, adult tissue repair, and
cancer. They activate canonical and noncanonical Wnt signaling cascades in target cells …

The process named endothelial‐to‐mesenchymal transition (EndMT) was observed for the
first time during the development of the chicken embryo several decades ago. Of interest …

Many adult stem cells display prolonged quiescence, promoted by cues from their niche.
Upon tissue damage, a coordinated transition to the activated state is required because non …

Notch1-4 receptors and their signaling pathways are expressed in almost all organ systems
and play a pivotal role in cell fate decision by coordinating cell proliferation, differentiation …

Endothelial cell–cell adherens junctions (AJs) supervise fundamental vascular functions,
such as the control of permeability and transmigration of circulating leukocytes, and the …

Correct organization of the vascular tree requires the balanced activities of several signaling
pathways that regulate tubulogenesis and vascular branching, elongation, and pruning …