Genome-wide association studies and functional genomics studies have linked specific cell
types, genes, and pathways to Alzheimer's disease (AD) risk. In particular, AD risk alleles …

Since their inception, genome-wide association studies (GWAS) have identified more than a
hundred thousand single nucleotide polymorphism (SNP) loci that are associated with …

We assembled an ancestrally diverse collection of genome-wide association studies
(GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls …

Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …

Background The remarkable growth of genome-wide association studies (GWAS) has
created a critical need to experimentally validate the disease-associated variants, 90% of …

Adipose tissue is a dynamic and metabolically active organ that plays a crucial role in
energy homeostasis and endocrine function. Recent advancements in lipidomics techniques …

Cardiovascular diseases (CVDs) are the leading cause of death and illness in Europe and
worldwide, responsible for a staggering 47% of deaths in Europe. Over the past few years …

Abstract Purpose of Review Genome-wide association studies have delineated the genetic
architecture of type 2 diabetes. While functional studies to identify target transcripts are …

Ceramides are signals of fatty acid excess that accumulate when a cell's energetic needs
have been met and its nutrient storage has reached capacity. As these sphingolipids accrue …

Genome-wide association studies (GWAS) have identified many disease-associated
variants, yet mechanisms underlying these associations remain unclear. To understand …