Asthma is a reversible airway obstruction that is characterized by constriction of airway
smooth muscle, hyper secretion of mucus, edema and airway hyper responsiveness (AHR) …

The local immune response is important to consider when the aim is to improve bone
regeneration. Recently T lymphocytes and their associated cytokines have been identified …

Despite conventional treatment modalities, gallbladder cancer (GBC) remains a highly lethal
malignancy. Prognostic biomarkers and effective adjuvant immunotherapy for GBC are not …

Th17 cells are a lineage of CD4+ T helper cells with Th17-specific transcription factors
RORγt and RoRα. Since its discovery in 2005, research on Th17 has been in rapid progress …

Background One of the main issues in pathogenesis of MS is Th17/Treg imbalance. There
are growing interests in nominating miRNAs involved in Th17 cell differentiation, suggesting …

Cytokines are highly pleiotropic ligands that regulate the immune response. Here, using
interleukin-6 (IL-6) as a model system, we perform detailed phosphoproteomic and …

Background Multiple sclerosis is an immune-mediated inflammatory disease of central
nervous system. MicroRNAs play important roles in autoimmune diseases such as MS …

We investigated the direct effect of PEGylated graphene oxide (P-GO) nanoparticles on the
differentiation, viability, and cytokine profile of activated T helper type 17 (Th17) in vitro. The …

Background Acute myeloid leukemia (AML) is an incurable disease with fatal infections or
relapse being the main causes of death in most cases. In particular, the severe infections …

Objective MicroRNAs (miRNA) are a class of non-coding RNAs which play key roles in post-
transcriptional gene regulation. Previous studies indicate that miRNAs are dysregulated in …