Adipogenesis is the process by which precursor stem cells differentiate into lipid laden
adipocytes. Adipogenesis is regulated by a complex and highly orchestrated gene …

The nuclear receptor PPARγ is a ligand-activated transcription factor that plays an important
role in the control of gene expression linked to a variety of physiological processes. PPARγ …

Cellular reprogramming of somatic cells to patient-specific induced pluripotent stem cells
(iPSCs) enables in vitro modelling of human genetic disorders for pathogenic investigations …

Obesity induced in mice by high-fat feeding activates the protein kinase Cdk5 (cyclin-
dependent kinase 5) in adipose tissues. This results in phosphorylation of the nuclear …

Summary Fibroblast growth factor-21 (FGF21) is a circulating hepatokine that beneficially
affects carbohydrate and lipid metabolism. Here, we report that FGF21 is also an inducible …

Infection and inflammation induce the acutephase response (APR), leading to multiple
alterations in lipid and lipoprotein metabolism. Plasma triglyceride levels increase from …

Despite a large need for new hypoglycemic therapies, given the epidemic of type 2 diabetes,
very few agents have been introduced during the past 20 years. The thiazolidinediones …

PPARγ is the functioning receptor for the thiazolidinedione (TZD) class of antidiabetes drugs
including rosiglitazone and pioglitazone. These drugs are full classical agonists for this …

Since the pathways of glycerolipid biosynthesis were elucidated in the 1950's, considerable
knowledge has been gained about the enzymes that catalyze the lipid biosynthetic reactions …

Metabolic syndrome is estimated to affect more than one in five adults, and its prevalence is
growing in the adult and pediatric populations. The most widely recognized metabolic risk …