Interruption of blood flow and gas exchange to the fetus in the perinatal period, known as
perinatal asphyxia, can, if significant, trigger a cascade of neuronal injury, leading on to …

Neonatal hypoxic ischemic encephalopathy (HIE) presents a significant clinical burden with
its high mortality and morbidity rates globally. Therapeutic hypothermia (TH) is now standard …

Objective To assess and contrast the incidence and severity of abnormalities on cerebral
magnetic resonance imaging (MRI) between infants with mild, moderate, and severe …

Neonatal brain injury and associated inflammation is more common in males. There is a well-
recognised difference in incidence and outcome of neonatal encephalopathy according to …

In 1998, a systemic fetal cytokine response, defined as a plasma interleukin-6 (IL-6) value
above 11 pg/mL, was reported to be a major independent risk factor for the subsequent …

Background Cytokines are possible mediators of neuroinflammation and associated with
adverse outcome in neonatal encephalopathy (NE). Our aim was to explore cytokine …

Objective To investigate the expression profile of microRNA (miRNA) in umbilical cord blood
from infants with hypoxic ischemic encephalopathy (HIE). Study design Full-term infants with …

The widespread introduction of therapeutic hypothermia as a standard of care in hypoxic–
ischemic encephalopathy (HIE) has brought increasing pressure on clinicians to make an …

Importance Neonatal hypoxic-ischemic encephalopathy (HIE) remains a significant cause of
neurologic disability. Identifying infants suitable for therapeutic hypothermia (TH) within a …

Background Infants with mild HIE are at risk of significant disability at follow-up. In the pre-
therapeutic hypothermia (TH) era, electroencephalography (EEG) within 6 hours of birth was …