TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
Involvement of neural transient receptor potential channels in peripheral inflammation
HA Silverman, A Chen, NL Kravatz… - Frontiers in …, 2020 - frontiersin.org
Transient receptor potential (TRP) channels are a superfamily of non-selective cation
channels that act as polymodal sensors in many tissues throughout mammalian organisms …
channels that act as polymodal sensors in many tissues throughout mammalian organisms …
Visceral pain
L Grundy, A Erickson, SM Brierley - Annual review of physiology, 2019 - annualreviews.org
Most of us live blissfully unaware of the orchestrated function that our internal organs
conduct. When this peace is interrupted, it is often by routine sensations of hunger and urge …
conduct. When this peace is interrupted, it is often by routine sensations of hunger and urge …
Calcium-permeable ion channels in pain signaling
The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …
dependent on a wide range of different types of voltage-and ligand-gated ion channels …
Neuroplasticity and dysfunction after gastrointestinal inflammation
SM Brierley, DR Linden - Nature reviews Gastroenterology & …, 2014 - nature.com
The gastrointestinal tract is innervated by several distinct populations of neurons, whose cell
bodies either reside within (intrinsic) or outside (extrinsic) the gastrointestinal wall. Normally …
bodies either reside within (intrinsic) or outside (extrinsic) the gastrointestinal wall. Normally …
TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain
B Liu, L Fan, S Balakrishna, A Sui, JB Morris, SE Jordt - Pain®, 2013 - Elsevier
Menthol, the cooling natural product of peppermint, is widely used in medicinal preparations
for the relief of acute and inflammatory pain in sports injuries, arthritis, and other painful …
for the relief of acute and inflammatory pain in sports injuries, arthritis, and other painful …
Visceral pain: the ins and outs, the ups and downs
S Sikandar, AH Dickenson - Current opinion in supportive and …, 2012 - journals.lww.com
Visceral pain: the ins and outs, the ups and downs : Current Opinion in Supportive and Palliative
Care Visceral pain: the ins and outs, the ups and downs : Current Opinion in Supportive and …
Care Visceral pain: the ins and outs, the ups and downs : Current Opinion in Supportive and …
Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders
Functional bowel disorders (FBD), mainly irritable bowel syndrome (IBS) and functional
constipation (FC, also called chronic idiopathic constipation), are very common worldwide …
constipation (FC, also called chronic idiopathic constipation), are very common worldwide …
The physiological effects and safety of peppermint oil and its efficacy in irritable bowel syndrome and other functional disorders
BP Chumpitazi, GL Kearns… - Alimentary pharmacology …, 2018 - Wiley Online Library
Background Peppermint oil has been used for centuries as a treatment for gastrointestinal
ailments. It has been shown to have several effects on gastrointestinal physiology relevant to …
ailments. It has been shown to have several effects on gastrointestinal physiology relevant to …