Heart failure is a common, costly, and debilitating syndrome that is associated with a highly
complex drug regimen, a large number of comorbidities, and a large and often disparate …

1928 Circulation October 22, 2013 mental health, functional status, activity limitations,
cancerrelated pain, and cancer-related anxiety) declined moderately to severely in 44%. 5 …

The risk of cardiotoxicity is the most serious drawback to the clinical usefulness of
anthracycline antineoplastic antibiotics, which include doxorubicin (adriamycin) …

Anthracyclines are used in over 50% of childhood cancer treatment protocols, but their
clinical usefulness is limited by anthracycline-induced cardiotoxicity (ACT) manifesting as …

Abstract Significance: Anthracyclines (doxorubicin, daunorubicin, or epirubicin) rank among
the most effective anticancer drugs, but their clinical usefulness is hampered by the risk of …

Background Doxorubicin chemotherapy is associated with cardiomyopathy. Dexrazoxane
reduces cardiac damage during treatment with doxorubicin in children with acute …

Aims Anthracycline‐induced cardiotoxicity (ACT) occurs in 57% of treated patients and
remains an important limitation of anthracycline‐based chemotherapy. In various genetic …

Purpose Doxorubicin causes cardiac injury and cardiomyopathy in children with acute
lymphoblastic leukemia (ALL). Measuring biomarkers during therapy might help …

Opinion statement Anthracyclines have been widely used in children and adults to treat
hematologic malignancies, soft-tissue sarcomas, and solid tumors. However, anthracyclines …

Anthracyclines remain among the most widely prescribed and effective anticancer agents.
Unfortunately, life-threatening cardiotoxicity continues to compromise their usefulness …