Since the introduction of the central dogma of molecular biology in 1958, various RNA
species have been discovered. Messenger RNAs transmit genetic instructions from DNA to …

The classic understanding of molecular disease-mechanisms is largely based on protein-
centric models. During the past decade however, genetic studies have identified numerous …

T cells are critical orchestrators of the adaptive immune response that optimally eliminate a
specific pathogen. Aberrant T-cell development and function are implicated in a broad range …

The innate immune system relies on a germ-line-encoded repertoire of pattern recognition
receptors (PRRs), activated by deeply conserved pathogen signatures, such as bacterial cell …

Infections in early life can elicit substantially different immune responses and pathogenesis
than infections in adulthood. Here, we investigate the consequences of murine …

Following antigen recognition, CD8+ T lymphocytes can follow different patterns of
differentiation, with the generation of different subsets characterized by distinct phenotypes …

Despite an ever-increasing appreciation of how protein-coding genes shape immune
responses, the molecular underpinnings of immune regulation remain incompletely …

Immune cell function is critically dependent on precise control over transcriptional output
from the genome. In this respect, integration of environmental signals that regulate gene …

Long noncoding RNAs (lncRNAs) are transcripts measuring> 200 bp in length and devoid of
protein-coding potential. LncRNAs exceed the number of protein-coding mRNAs and …

In parasite and viral infections, aberrant B cell responses can suppress germinal center
reactions thereby blunting long-lived memory and may provoke immunopathology including …