The role of host genetic factors in coronavirus susceptibility: review of animal and systematic review of human literature

M LoPresti, DB Beck, P Duggal, DAT Cummings… - The American Journal of …, 2020 - cell.com
The SARS-CoV-2 pandemic raises many scientific and clinical questions. These include
how host genetic factors affect disease susceptibility and pathogenesis. New work is …

[HTML][HTML] Factors modulating COVID-19: A mechanistic understanding based on the adverse outcome pathway framework

LA Clerbaux, MC Albertini, N Amigo… - Journal of Clinical …, 2022 - mdpi.com
Addressing factors modulating COVID-19 is crucial since abundant clinical evidence shows
that outcomes are markedly heterogeneous between patients. This requires identifying the …

Genetic landscape of the ACE2 coronavirus receptor

Z Yang, E Macdonald-Dunlop, J Chen, R Zhai, T Li… - Circulation, 2022 - Am Heart Assoc
Background: SARS-CoV-2, the causal agent of COVID-19, enters human cells using the
ACE2 (angiotensin-converting enzyme 2) protein as a receptor. ACE2 is thus key to the …

Emerging potential mechanisms and predispositions to the neurological manifestations of COVID-19

A Jesuthasan, F Massey, H Manji, MS Zandi… - Journal of the …, 2021 - Elsevier
A spectrum of neurological disease associated with COVID-19 is becoming increasingly
apparent. However, the mechanisms behind these manifestations remain poorly …

Genetic variations affecting ACE2 protein stability in minority populations

V Mahase, A Sobitan, R Rhoades, F Zhang… - Frontiers in …, 2022 - frontiersin.org
While worldwide efforts for improving COVID-19 vaccines are currently considered a top
priority, the role of the genetic variants responsible for virus receptor protein stability is less …

Bioinformatic Analysis of Missense Mutations Affecting ACE2–SARS-CoV-2 Complexes

V Mahase - 2023 - search.proquest.com
Discovering ACE2 as the receptor for SARS-CoV-2 Spike (S) has catalyzed an influx of
research to understand infection pathology and develop drugs. Nonetheless, disparities in …

Linkage between ACE2 Gene Polymorphisms and SARS-CoV-2 infection in Burkina Faso, sub-Saharan Africa

A Yonli, J Simpore, H Ouedraogo… - … of Experimental and …, 2024 - jemb.bio.uaic.ro
The ACE2 gene polymorphisms (rs143936283, rs146676783, and rs4646116) in infected
and noninfected persons by SARS-CoV-2 in Burkina Faso. Our cross-sectional study …

Variants of the ACE2 Gene: The SARV-CoV2 Receptor in Different Human Populations

LC Reis, WFDS Junior - International Journal of Medical Reviews, 2022 - ijmedrev.com
In December 2019, a respiratory disease called Coronavirus Disease 2019 (COVID-19)
emerged in Wuhan, China. In thefollowing year, it was considered as a pandemic caused by …

[PDF][PDF] SARS-CoV-2 receptor and renin-angiotensin system regulation: impact of genetic variants in ACE2 gene

J de Oliveira Cruz, V da Conquista - academia.edu
The ACE2 has a physiological role in the regulation of the Renin-Angiotensin System. It is
also described your function as a receptor for SARS-CoV-2 and other coronaviruses …