Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a
family of small conserved eukaryotic proteins that mediate membrane fusion between …

Compounds with a nitrobenzoxadiazole (NBD) skeleton exhibit prominent useful properties
including environmental sensitivity, high reactivity toward amines and biothiols (including …

SNARE proteins and Sec1/Munc18 (SM) proteins constitute the core molecular engine that
drives nearly all intracellular membrane fusion and exocytosis. While SNAREs are known to …

Chemical neurotransmission is the major mechanism of neuronal communication.
Neurotransmitters are released from secretory organelles, the synaptic vesicles (SVs) via …

Synaptic vesicles are storage organelles for neurotransmitters. They pass through a
trafficking cycle and fuse with the pre-synaptic membrane when an action potential arrives at …

Vesicle-associated membrane protein 2 (VAMP2, also known as synaptobrevin-2), encoded
by VAMP2 in humans, is a key component of the soluble N-ethylmaleimide-sensitive factor …

As one of the leading causes of morbidity and mortality worldwide, diabetes affects an
estimated 422 million adults, and it is expected to continue expanding such that by 2050 …

Physiological membrane vesicles are built to separate reaction spaces in a stable manner,
even when they accidentally collide or are kept in apposition by spatial constraints in the …

Membrane proteins control and shape membrane trafficking processes. The role of protein
structure in shaping cellular membranes is well established. However, a significant fraction …

Microtubules are important components of the eukaryotic cytoskeleton. Their structural
organization is regulated by nucleotide binding and many microtubule-associated proteins …