Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective

S Nattel, J Heijman, L Zhou, D Dobrev - Circulation research, 2020 - Am Heart Assoc
Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity
and mortality. There have been significant management advances over the past 2 decades …

2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation

H Calkins, G Hindricks, R Cappato, YH Kim… - Ep …, 2018 - academic.oup.com
AFL atrial flutter AH arterial hypertension ANS autonomic nervous system APD action
potential duration ARREST-AF Aggressive Risk Factor Reduction Study for Atrial Fibrillation …

Atrial myocyte NLRP3/CaMKII nexus forms a substrate for postoperative atrial fibrillation

J Heijman, AP Muna, T Veleva, CE Molina… - Circulation …, 2020 - Am Heart Assoc
Rationale: Postoperative atrial fibrillation (POAF) is a common and troublesome
complication of cardiac surgery. POAF is generally believed to occur when postoperative …

JCS/JHRS 2020 guideline on pharmacotherapy of cardiac arrhythmias

K Ono, Y Iwasaki, M Akao, T Ikeda, K Ishii… - Circulation …, 2022 - jstage.jst.go.jp
The Japanese Circulation Society (JCS) published the “Guidelines for Pharmacological
Treatment of Arrhythmia” in 2004, and a revised edition was published in 2009. 1 Both …

Calcium signaling and cardiac arrhythmias

AP Landstrom, D Dobrev, XHT Wehrens - Circulation research, 2017 - Am Heart Assoc
There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …

2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: executive summary: a report of the American College of Cardiology/American …

CT January, LS Wann, JS Alpert, H Calkins… - Circulation, 2014 - Am Heart Assoc
The recommendations listed in this document are, whenever possible, evidence based. An
extensive evidence review was conducted, focusing on 2006 through October 2012 and …

2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task …

CT January, LS Wann, JS Alpert, H Calkins… - Journal of the American …, 2014 - jacc.org
The recommendations listed in this document are, whenever possible, evidence based. An
extensive evidence review was conducted, focusing on 2006 through October 2012 and …

Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression

J Heijman, N Voigt, S Nattel, D Dobrev - Circulation research, 2014 - Am Heart Assoc
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …

Pathophysiological mechanisms of atrial fibrillation: a translational appraisal

U Schotten, S Verheule, P Kirchhof… - Physiological …, 2011 - journals.physiology.org
Atrial fibrillation (AF) is an arrhythmia that can occur as the result of numerous different
pathophysiological processes in the atria. Some aspects of the morphological and …

Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation

N Voigt, J Heijman, Q Wang, DY Chiang, N Li… - Circulation, 2014 - Am Heart Assoc
Background—Electrical, structural, and Ca2+-handling remodeling contribute to the
perpetuation/progression of atrial fibrillation (AF). Recent evidence has suggested a role for …